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S-(4-NITROBENZYL)-6-THIOINOSINE

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:S-(4-Nitrobenzyl)-6-thio inosine
CAS:38048-32-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Nanjing Baifuli Technology Co., Ltd.
Tel: +86-15335185688
Email: sales@unisyn.cn
Products Intro: Product Name:S-(4-Nitrobenzyl)-6-thioinosine
CAS:38048-32-7
Purity:98% Package:On Request
Company Name: NewCan Biotech Limited
Tel: +86-0571-86912261 +8613735419629
Email: sales@newcanbio.com
Products Intro: Product Name:S-(4-Nitrobenzyl)-6-thioinosine(NBTI,NBMPR)
CAS:38048-32-7
Purity:97% Package:mgs,gs,kgs
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:NBMPR
CAS:38048-32-7
Purity:98% Package:250mg Remarks:V2200
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:Nitrobenzylthioinosine；NBMPR
CAS:38048-32-7
Package:100 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
S-(4-NITROBENZYL)-6-THIOINOSINE Basic information
Product Name:S-(4-NITROBENZYL)-6-THIOINOSINE
Synonyms:S-(P-NITROBENZYL)-6-THIOINOSINE;S-(4-NITROBENZYL)-6-THIOINOSINE;NBTI;4-nitrobenzylthioinosine;6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purin;6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purine;6-(p-nitrobenzylthio)inosine;6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE
CAS:38048-32-7
MF:C17H17N5O6S
MW:419.41
EINECS:253-753-4
Product Categories:Bases & Related Reagents;Heterocycles;Inhibitors;Nucleotides;Sulfur & Selenium Compounds
Mol File:38048-32-7.mol
S-(4-NITROBENZYL)-6-THIOINOSINE Structure
S-(4-NITROBENZYL)-6-THIOINOSINE Chemical Properties
Melting point 187-190 °C(lit.)
Boiling point 770.2±70.0 °C(Predicted)
density 1.3904 (rough estimate)
refractive index 1.6460 (estimate)
storage temp. 2-8°C
solubility 0.1 M HCl: slightly soluble
form solid
pka13.08±0.70(Predicted)
color white
CAS DataBase Reference38048-32-7(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
WGK Germany 3
RTECS UO9025000
HS Code 29349990
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
S-(4-NITROBENZYL)-6-THIOINOSINE Usage And Synthesis
Chemical PropertiesOff-White Solid
UsesIt is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardio
UsesS-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.
DefinitionChEBI: NBMPR is a purine nucleoside.
General DescriptionS-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S6-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport.
Biological ActivityEquilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).
Biochem/physiol ActionsInhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle.
storageStore at +4°C
Tag:S-(4-NITROBENZYL)-6-THIOINOSINE(38048-32-7) Related Product Information
S-(2-HYDROXY-5-NITROBENZYL)-6-THIOINOSINE S-(P-NITROBENZYL)-6-THIOINOSINE, [3H]- NITROBENZYLTHIOINOSINE, [BENZYL-3H]- S-(4-NITROBENZYL)-6-THIOINOSINE 6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE-5'-MONOPHOSPHATE, DISODIUM SALT NBTGR