| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
177-54423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:ASLAN003
CAS:2305936-56-3
Purity:98% HPLC LCMS Package:1G;100G
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| Product Name: | TD-165 | | Synonyms: | TD-165;(2S,4R)-1-((2S)-2-(11-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)undecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;TD-165, 10 mM in DMSO | | CAS: | 2305936-56-3 | | MF: | C46H59N7O8S | | MW: | 870.07 | | EINECS: | | | Product Categories: | | | Mol File: | 2305936-56-3.mol |  |
| | TD-165 Chemical Properties |
| Boiling point | 1096.3±65.0 °C(Predicted) | | density | 1.292±0.06 g/cm3(Predicted) | | solubility | DMSO : 50 mg/mL (57.47 mM; Need ultrasonic) | | form | Solid | | pka | 10.75±0.40(Predicted) | | color | White to yellow |
| | TD-165 Usage And Synthesis |
| Uses | TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a?cereblon (CRBN)?ligand binding group, a linker and an?von Hippel-Landau (VHL)?binding group[1]. | | Biological Activity | TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1].
TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4 nM and 99.6%, respectively[1].TD-165 (0.1-10 μM; 24 hours) leads to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells[1]. | | IC 50 | Cereblon: 20.4 nM (DC50) | | References | [1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.Sci Rep. 2019 Dec 23;9(1):19654. |
| | TD-165 Preparation Products And Raw materials |
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