| Company Name: |
Atlas antibodies |
| Tel: |
46-854595850 |
| Email: |
order@atlasantibodies.com |
| Company Name: |
Merck KGaA |
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
| Company Name: |
Upstate |
| Tel: |
434 975 4300 |
| Email: |
info@upstate.com |
|
| | ANTI-TYK2 Basic information |
| Product Name: | ANTI-TYK2 | | Synonyms: | Anti-TYK2 (1046-1060) antibody produced in rabbit;Anti-TYK2 (106-120) antibody produced in rabbit;Anti-TYK2 antibody produced in rabbit;Monoclonal Anti-TYK2 antibody produced in mouse;ANTI-HUMAN TYK2;ANTI-TYK2;RABBIT ANTI-HUMAN TYK2;Anti-Non-receptor tyrosine-protein kinase TYK2 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-TYK2 Structure]() |
| | ANTI-TYK2 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution | | biological source | rabbit |
| Storage Class | 10 - Combustible liquids |
| | ANTI-TYK2 Usage And Synthesis |
| Uses | This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. (provided by RefSeq) | | Biological Activity | TYK2 (Tyrosine kinase 2) plays an important role in cell signaling by multiple cytokines via the JAK-ST at pathway. Tyk2 interacts with type I IFN, p40-sharing IL-12 and IL-23, IL-6, and IL-10 family receptors and helps in immunomodulation. On binding, TYK2 is phosphorylated and co-activated with JAK1 and/or JAK2. It has been suggested th at TYK2 is required for the surface expression of human IL-10R as well as human type I IFNR. TYK2 is also involved in the differentiation of immune cells, such as B cells, T helper cells and natural killer cells. Abnormal TYK2 expression is implicated in the etiology of several auto-immune diseases such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus. Studies show th at TYK2 rs34536443 polymorphism is associated with endometriosis and related infertility. |
| | ANTI-TYK2 Preparation Products And Raw materials |
|