4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Suppliers list

Company Name:	Shanghai Boc Chemical Co., Ltd.
Tel:	021-34975602; +8618721111801
Email:	shangli@bocchem.com
Products Intro:	Product Name:4-Chloro-7H-pyrrolo[2,3-d]pyrimidine CAS:3680-69-1 Purity:0.98 Package:50KG；5KG;1KG

Company Name:	Shanghai Rochi Pharmaceutical Co.,Ltd.
Tel:	21-38751876 +8615000076078
Email:	info@rochipharma.com
Products Intro:	Product Name: 4-Chloro-7H-pyrrolo[2,3,-d]pyrimidine CAS:3680-69-1 Purity:99%min Package:1kg 5kg 10kg 25kg

Company Name:	changzhou huayang technology co., ltd
Tel:	+8615250961469
Email:	2571773637@qq.com
Products Intro:	Product Name:4-Chloro-7H-pyrrolo[2,3-d]pyrimidine CAS:3680-69-1

Company Name:	Hangzhou Qiwei Pharmatech Co.,Ltd
Tel:	13282840061
Email:	mw@qwpharmatech.com
Products Intro:	Product Name:4-Chloro-7H-pyrrolo[2,3-d]pyrimidine CAS:3680-69-1 Purity:0.99 Package:5KG;1KG

Company Name:	Huanfu Industrial Co.，（Shanghai）Ltd.
Tel:	+86-18001856580 +86-18001856580
Email:	2415195517@qq.com
Products Intro:	Product Name:4-Chloro-7H-pyrrolo[2,3-d]pyrimidine CAS:3680-69-1 Package:500g/;1kg/;10kg/;25kg/;100kg/ Remarks:99.5%HPLC

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine manufacturers

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine: properties, applications and safety
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine is a versatile compound used in pharmaceutical synthesis with potential applications in d....
Oct 10，2023

4-Chloro-7H-pyrrolo[2,3-d] pyrimidine— a medical intermediate
Being an important intermediate in medicine, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine had been widely used in the synthesis of ma....
Dec 18，2019

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Basic information

Product Name:	4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
Synonyms:	4-chloro-7,7a-dihydro-4aH-pyrrolo[2,3-d]pyrimidine;4-chloro-7H-pyrrolo[2,3-d]pyrimidine(SALTDATA: FREE);4-Chloropyrrolo[2,3-d]pyriMidine 6-Chloro-7-deazapurine;7H-pyrrolo[2,3-d]pyriMidine, 6-Chloro-7-deazapurine;4-chloro-7H-pyrollo[2,3d]pyriMidine;4-Methyl-1,3-thiazole-2,5-diaMine;Tofacitinib interMediate C;6-Chloro-7-deazapurine ,98%
CAS:	3680-69-1
MF:	C6H4ClN3
MW:	153.57
EINECS:	628-079-2
Product Categories:	Fused Ring Systems;Heterocyclic Building Blocks;Heterocycle-Pyrimidine series;Baricitinib;Ruxolitinib;Tofacitinib;Heterocycles series;Halides;Pyrimidine;Heterocycles;Bases & Related Reagents;Intermediates;Nucleotides;Heterocyclic Compounds;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;CHIRAL CHEMICALS;Naphthyridine,Quinoline;3680-69-1
Mol File:	3680-69-1.mol

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties

Melting point	188-194 °C
Boiling point	289.2±50.0 °C(Predicted)
density	1.61±0.1 g/cm3(Predicted)
vapor pressure	0Pa at 25℃
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Soluble in DMSO, ethyl acetate and methanol.
form	Crystalline Powder
pka	11.42±0.20(Predicted)
color	White to tan
InChI	InChI=1S/C6H4ClN3/c7-5-4-1-2-8-6(4)10-3-9-5/h1-3H,(H,8,9,10)
InChIKey	BPTCCCTWWAUJRK-UHFFFAOYSA-N
SMILES	C1=NC(Cl)=C2C=CNC2=N1
LogP	0.858 at 30℃
CAS DataBase Reference	3680-69-1(CAS DataBase Reference)

Safety Information

MSDS Information

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Usage And Synthesis

Uses	4-Chloro-7H-pyrrolo[2,3-d] pyrimidine is an important pharmaceutical intermediate, which is widely used in the synthesis of many pharmaceutical intermediates at home and abroad. Including CP690550, CGP76030 and so on, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the scaffold for many commercially available drugs. Also, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the intermediate of the bulk drug, Tofatinib, which was widely used in treatment of adult patients with moderate to severe rheumatoid arthritis with inadequate or intolerant methotrexate response.
Chemical Properties	Lightbrown to brown crystalline powder
Uses	4-Chloro-7H-pyrrolo[2,3-d]pyrimidine is used in the manufacture of Tofacitinib citrate.
Synthesis	The preparation process of pyrimidine includes the first α -alkylation reaction between diethyl malonate and allyl bromide, and the subsequent cyclization reaction with amidine to obtain a six-membered ring of bislactam. The chlorination of carbonyl with phosphorus oxychloride to obtain dichloro pyrimidine ring, followed by the oxidation of the terminal double bond with potassium osmate hydrate and sodium periodate to obtain the aldehyde group. The final reaction with ammonia water to produce SNAr/cyclization reaction, a five-step reaction, total yield of 45.8% to obtain 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine.

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials	Sodium-->Phosphorus oxychloride-->Potassium carbonate-->Ammonium chloride-->Ethyl cyanoacetate-->Thiourea-->Sodium iodide-->Bromoacetaldehyde diethyl acetal-->RANEY NICKEL-->Pyrrolo[2,3-d]pyrimidin-4-ol
Preparation Products	DEAZAPURINE-->5-iodo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine-->4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile-->(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate-->4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine-->5-IODOTUBERCIDIN

Tag:4-Chloro-7H-pyrrolo[2,3-d]pyrimidine(3680-69-1) Related Product Information

Indole Pyrimidine Polyvinylpyrrolidone Epichlorohydrin 1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE N-Methyl-2-pyrrolidone Sodium thiosulfate pentahydrate 4-Chloropyrimidine 6-Chloropurine DEAZAPURINE N-((3R,4R)-1-benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Methyl 4-chloropicolinate 4-Chloropyridinium chloride 2-Pyridinecarbonitrile,4-hydroxy-(9CI) Lithium hydroxide monohydrate N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE