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| | FLUTICASONE PROPIONATE INTERMEDIATE Basic information |
| Product Name: | FLUTICASONE PROPIONATE INTERMEDIATE | | Synonyms: | Androsta-1,4-diene-17- carbothioic acid, 6,9-difluoro -11-hydroxy-16-Methyl-3-oxo-17-(1-oxopropoxy)-, (6α,11β, 16α,17α)-;Fn-1;Fluticasone intermediate FN-1(1);FLUTICASONE PROPIONATE INTERMEDIATE;6,9-DIFLUORO-11B-HYRDOXY-16-METHYL-3-OXO-17-PROPIONYLOXYANDROSTA-1,4-DIENE-17B-CARBPTHIOCACID;(6alpha,11beta,,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxo-propoxy)androsta-1,4-diene-17-carbothioic acid;6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)-androsta-1,4-diene-17β-carbothioic Acid;6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1- | | CAS: | 80474-45-9 | | MF: | C24H30F2O5S | | MW: | 468.56 | | EINECS: | 617-084-5 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Steroids | | Mol File: | 80474-45-9.mol |  |
| | FLUTICASONE PROPIONATE INTERMEDIATE Chemical Properties |
| Melting point | 158-160?C | | Boiling point | 563.3±50.0 °C(Predicted) | | density | 1.31 | | vapor pressure | 6Pa at 20℃ | | storage temp. | -20°C Freezer | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | pka | 2.99±0.70(Predicted) | | form | Solid | | color | White to Off-White | | Water Solubility | 50mg/L at 20℃ | | Stability: | Air Sensitive | | LogP | 2.64 |
| | FLUTICASONE PROPIONATE INTERMEDIATE Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | An intermediate in the synthesis of Fluticasone Propionate. | | Flammability and Explosibility | Not classified |
| | FLUTICASONE PROPIONATE INTERMEDIATE Preparation Products And Raw materials |
| Raw materials | 3-(3,4-Dimethoxyphenyl)-pentane-2-one-->THIOPROPIONIC ACID-->FLUTICASONE PROPIONATE, 17-BETA CARBOXYLIC ACID-->Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6a,11b,16a,17a)--->(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid-->Diethylamine-->Propionyl chloride | | Preparation Products | Fluticasone propionate |
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