| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:c-met-IN-1;cmetIN1,c met IN 1
CAS:2084836-84-8
Purity:98% Package:5 mg
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| | c-met-IN-1 Basic information |
| Product Name: | c-met-IN-1 | | Synonyms: | c-met-IN-1;cmetIN1,c met IN 1;1H-Imidazole-4-carboxamide, N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-4-quinolinyl]oxy]phenyl]-1-(2-methoxyphenyl)- | | CAS: | 2084836-84-8 | | MF: | C35H37FN6O5 | | MW: | 640.7 | | EINECS: | | | Product Categories: | | | Mol File: | 2084836-84-8.mol |  |
| | c-met-IN-1 Chemical Properties |
| Boiling point | 735.6±60.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 10.22±0.70(Predicted) |
| | c-met-IN-1 Usage And Synthesis |
| Description | c-met-IN-1 (compound 16) is a potent and selective c-Met inhibitor, with IC50 of 1.1 nM, with antitumor activity.[1].
IC50: 1.1 nM (c-Met)[1] c-met-IN-1 (compound 16) exhibits high selectivity and remarkable cytotoxicity against HT-29, MKN-45 and A549 cells with IC50 values of 0.08 μM, 0.22 μM and 0.07 μM, respectively[1]. | | References | [1]. Wang X, et al. Design, synthesis and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives as selective c-Met inhibitors. Bioorg Med Chem. 2017 Feb 1;25(3):886-896. |
| | c-met-IN-1 Preparation Products And Raw materials |
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