2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-

2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]- Suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354; +17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:VU0424465 CAS:1428630-85-6 Package:50mg;2400USD\|10mg;578USD

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354;
Email:	support@targetmol.com
Products Intro:	Product Name:VU0424465；ML 273;VU 0424465;VU-0424465;ML-273;ML273 CAS:1428630-85-6 Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	Aladdin Scientific
Tel:
Email:	tp@aladdinsci.com
Products Intro:	Product Name:VU 0424465 CAS:1428630-85-6 Purity:>=98%(HPLC) Package:$175.9/10mg;$740.9/50mg;Bulk package Remarks:98%(HPLC)

Company Name:	Shanghai Beckham Medical Technology Co., Ltd
Tel:	13816613772
Email:	huahero21@sina.com
Products Intro:	Product Name:VU0424465 CAS:1428630-85-6 Purity:98% Package:1g

Company Name:	Shanghai Hongye Biotechnology Co. Ltd
Tel:	400-9205774
Email:	sales@glpbio.cn
Products Intro:	Product Name:VU 0424465 CAS:1428630-85-6 Purity:>98% Package:1mg;10mg;50mg;100mg;

2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]- manufacturers

2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]- Basic information

Product Name:	2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-
Synonyms:	2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-;VU 0424465;ML 273;ML-273;ML273
CAS:	1428630-85-6
MF:	C19H19FN2O2
MW:	326.36
EINECS:
Product Categories:
Mol File:	1428630-85-6.mol

2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]- Chemical Properties

Safety Information

MSDS Information

2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]- Usage And Synthesis

Uses	VU0424465 is a potent and partial PAM (positive allosteric modulator)-agonist for mGlu5 mediated iCa2+ mobilization. VU0424465 exhibits high affinity at MPEP allosteric binding site, with a Ki value of 11.8 nM. VU0424465 is also a agonist for pERK1/2 in cortical neurons[1][2].
IC 50	mGlu₅
storage	Store at -20°C
References	[1] Sengmany K, et al. Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery. Neuropharmacology. 2017;115:60-72. DOI:10.1016/j.neuropharm.2016.07.001 [2] Rook JM, Noetzel MJ, Pouliot WA, et al. Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity. Biol Psychiatry. 2013;73(6):501-509. DOI:10.1016/j.biopsych.2012.09.012

2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]- Preparation Products And Raw materials

Tag:2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-(1428630-85-6) Related Product Information

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