7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- manufacturers
- SIRT2-IN-11
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- $443.00
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2026-07-15
- CAS:1005095-06-6
- Purity:
- Supply Ability: 10g
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| | 7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- Basic information |
| Product Name: | 7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- | | Synonyms: | 7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl-;WAY-324197;6-Phenyl-5,6,6a,7,8,9,10,10a-octahydro-7,10-methanophenanthridine-2-carboxamide;SIRT2-IN-11 | | CAS: | 1005095-06-6 | | MF: | C21H22N2O | | MW: | 318.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1005095-06-6.mol |  |
| | 7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- Chemical Properties |
| Boiling point | 494.0±45.0 °C(Predicted) | | density | 1+-.0.06 g/cm3(Predicted) | | pka | 16.93±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | 7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- Usage And Synthesis |
| Uses | SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers[1]. | | IC 50 | SIRT2: 18.5 μM (IC50); SIRT1: 118.4 μM (IC50) | | References | [1] Hoffmann G, et al. A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer. J Biol Chem. 2014 Feb 21;289(8):5208-16. DOI:10.1074/jbc.M113.487736 |
| | 7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- Preparation Products And Raw materials |
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