7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl-

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7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- Suppliers list
Company Name: Aladdin Scientific
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Email: tp@aladdinsci.com
Products Intro: Product Name:WAY-324197
CAS:1005095-06-6
Purity:95% Package:$70.9/1mg;$253.9/5mg;$950.9/25mg;$1321.9/50mg;$2119.9/100mg;Bulk package Remarks:95%
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:SIRT2-IN-11
CAS:1005095-06-6
Package:100mg;2230USD|50mg;1390USD|25mg;1070USD
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 021-61312847; 18021002903
Email: 3008007409@qq.com
Products Intro: Product Name:WAY-324197
CAS:1005095-06-6
Purity:95% Package:100mg Remarks:S23721
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Email: klq@cw-bio.com
Products Intro: Product Name:WAY-324197
CAS:1005095-06-6
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
Company Name: Zhejiang Huida Biotech Co., LTD  
Tel: 0571-89903022 18679456698
Email: zilong@hizyme.com
Products Intro: Product Name:WAY-324197
CAS:1005095-06-6
Purity:95% Package:100mg；200mg

7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- manufacturers

  • SIRT2-IN-11
  • SIRT2-IN-11 pictures
  • $443.00
  • 2026-04-20
  • CAS:1005095-06-6
  • Purity:
  • Supply Ability: 10g
7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- Basic information
Product Name:7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl-
Synonyms:7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl-;WAY-324197;6-Phenyl-5,6,6a,7,8,9,10,10a-octahydro-7,10-methanophenanthridine-2-carboxamide;SIRT2-IN-11
CAS:1005095-06-6
MF:C21H22N2O
MW:318.41
EINECS:
Product Categories:
Mol File:1005095-06-6.mol
7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- Structure
7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- Chemical Properties
Boiling point 494.0±45.0 °C(Predicted)
density 1+-.0.06 g/cm3(Predicted)
pka16.93±0.40(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- Usage And Synthesis
UsesSIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers[1].
IC 50SIRT2: 18.5 μM (IC50); SIRT1: 118.4 μM (IC50)
References[1] Hoffmann G, et al. A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer. J Biol Chem. 2014 Feb 21;289(8):5208-16. DOI:10.1074/jbc.M113.487736
7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- Preparation Products And Raw materials
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