Company Name: |
Shanghai potentpharm CO.,Ltd
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Tel: |
(86) 21 51969655 |
Email: |
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Products Intro: |
Product Name:4-chloroquinoline-2-carbonitrile CAS:4552-43-6 Purity:97% Package:1g;5g;25g;100g;500g;1kg
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Company Name: |
Shanghai Hekang Biotechnology Co., Ltd.
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Tel: |
18939837085 |
Email: |
youchemicals@gmail.com |
Products Intro: |
Product Name:4-Chloro-2-Cyanoquinoline CAS:4552-43-6 Purity:95+% Package:1g, 5g, 10g, 25g, 100g, 1kg, 1000kg Remarks:C2721
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Company Name: |
Synchem OHG
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Tel: |
+49 5662 408730 |
Email: |
info@synchem.de |
Products Intro: |
Product Name:4-Chloro-2-cyanoquinoline CAS:4552-43-6
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Company Name: |
Changzhou Hopschain Chemical Co.,Ltd.
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Tel: |
0519-85528066 13775048983 |
Email: |
sales@hopschem.com |
Products Intro: |
Product Name:4-chloroquinoline-2-carbonitrile CAS:4552-43-6 Purity:95+% Package:100mg;250mg;500mg;1g;2.5g;5g;10g
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| 4-chloroquinoline-2-carbonitrile Basic information |
| 4-chloroquinoline-2-carbonitrile Chemical Properties |
Melting point | 109 °C | Boiling point | 320.4±22.0 °C(Predicted) | density | 1.36±0.1 g/cm3(Predicted) | storage temp. | 2-8°C | pka | -2.08±0.50(Predicted) |
| 4-chloroquinoline-2-carbonitrile Usage And Synthesis |
Preparation | synthesis of 4-chloroquinoline-2-carbonitrile: To a solution of 2,4-dichloroquinoline (444 mg, 2.24 mmol) in DMF (5 mL) was added zinc cyanide (117 mg, 1.14 mmol) and Pd(PPh3)4 (259 mg, 0.22 mmol). The reaction mixture was stirred at 120 °C for 1 h. A saturated NH4Cl solution (20 mL) was added and the mixture was extracted with ethyl acetate (3x5 mL). The organic layer was washed with a NaCl solution (5mL) and dried over sodium sulfate, filtered and evaporated. The product was further purified by chromatography on silica gel eluting with cyclohexane/ethyl acetate (95:5) to give 4-chloroquinoline-2-carbonitrile (392 mg, 2.085 mmol, 93 %) as a white solid. |
| 4-chloroquinoline-2-carbonitrile Preparation Products And Raw materials |
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