| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:L-371,257;1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-Methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine
CAS:162042-44-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | L371,257 Basic information |
| Product Name: | L371,257 | | Synonyms: | L371,257;1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine;1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one;2H-3,1-Benzoxazin-2-one, 1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro-;257;L-371;L371,257,L 371,257 | | CAS: | 162042-44-6 | | MF: | C28H33N3O6 | | MW: | 507.58 | | EINECS: | | | Product Categories: | | | Mol File: | 162042-44-6.mol |  |
| | L371,257 Chemical Properties |
| Boiling point | 728.9±60.0 °C(Predicted) | | density | 1.282±0.06 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | Soluble to 10 mM in DMSO with gentle warming | | form | Powder | | pka | 0.73±0.20(Predicted) |
| | L371,257 Usage And Synthesis |
| Uses | L-371,257 is a potent antagonist of oxytocin-induced contractions of the rat uterus in vitro and in vivo and has significant oral bioavailability in rats. | | Biological Activity | Potent, high affinity human oxytocin (OT) receptor antagonist (K i = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V 1a and V 2 . Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA 2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Orally active. | | storage | Store at RT |
| | L371,257 Preparation Products And Raw materials |
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