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Diethyl malonate

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Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: CAS:105-53-3
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
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CAS:105-53-3
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Products Intro: Product Name:Diethyl malonate
CAS:105-53-3
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
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Products Intro: Product Name:Diethyl malonate
CAS:105-53-3
Company Name: Mainchem Co., Ltd.
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Products Intro: Product Name:Diethyl malonate
CAS:105-53-3

Lastest Price from Diethyl malonate manufacturers

  • Diethyl malonate
  • US $1.00 / Kg/Drum
  • 2019-07-14
  • CAS:105-53-3
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 99999tons
  • Diethyl malonate
  • US $1.00 / kg
  • 2019-07-06
  • CAS: 105-53-3
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100KG
Diethyl malonate Basic information
Description References
Product Name:Diethyl malonate
Synonyms:MALONIC ACID DIETHYL ESTER;MALONIC ESTER;ETHYL MALONATE;Ethyl propanedioate;FEMA 2375;DEM;DICARBETHOXYMETHANE;DIETHYL MALONATE
CAS:105-53-3
MF:C7H12O4
MW:160.17
EINECS:203-305-9
Product Categories:-;Building Blocks;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Esters;Organics;Organic Building Blocks
Mol File:105-53-3.mol
Diethyl malonate Structure
Diethyl malonate Chemical Properties
Melting point -50 °C
Boiling point 199 °C(lit.)
density 1.055 g/mL at 25 °C(lit.)
vapor density 5.52 (vs air)
vapor pressure 1 mm Hg ( 40 °C)
refractive index n20/D 1.413(lit.)
FEMA 2375 | DIETHYL MALONATE
Fp 212 °F
storage temp. Store below +30°C.
solubility 20.8g/l (External MSDS)
pka13.5(at 25℃)
form Liquid
explosive limit0.8-12.8%(V)
Water Solubility Miscible with ethyl alcohol, ether, chloroform and benzene. Slightly miscible with water.
Merck 14,3823
JECFA Number614
BRN 774687
Stability:Stable. Combustible. Incompatible with strong oxidizing agents,
InChIKeyIYXGSMUGOJNHAZ-UHFFFAOYSA-N
CAS DataBase Reference105-53-3(CAS DataBase Reference)
NIST Chemistry ReferencePropanedioic acid, diethyl ester(105-53-3)
EPA Substance Registry SystemPropanedioic acid, diethyl ester(105-53-3)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38-36
Safety Statements 24/25-26
WGK Germany 1
RTECS OO0700000
Autoignition Temperature435 °C DIN 51794
Hazard Note Irritant
TSCA Yes
HS Code 29171910
ToxicityLD50 orally in Rabbit: 15720 mg/kg LD50 dermal Rabbit > 16000 mg/kg
MSDS Information
ProviderLanguage
Ethyl propanedioate English
SigmaAldrich English
ACROS English
ALFA English
Diethyl malonate Usage And Synthesis
DescriptionAs an organic compound, diethyl malonate belongs to the diethyl ester of malonic acid, which is present naturally in guava fruits, melons, grapes, pineapples, blackberries and strawberries as a colorless liquid with an apple-like odor. It is a flavor ingredient commonly found in perfumes, artificial flavorings, alcoholic beverages, various wines and spirits due to its natural pleasant odor. It is also used as an essential intermediate in the syntheses of numerous pharmaceuticals, such as barbiturates, vitamins B1 and B6, non-steroidal anti-inflammatory agents. Besides, diethyl malonate is also involved in organic synthesis of other compounds, such as alpha-aryl malonates, mono-substituted and di-substituted acetic acid. And it can react with benzaldehyde for the production of diethyl benzylidenemalonate in Knoevenagel condensation reaction.
Referenceshttps://en.wikipedia.org/wiki/Diethyl_malonate
https://pubchem.ncbi.nlm.nih.gov/compound/7761#section=Safety-and-Hazards
https://www.alfa.com/zh-cn/catalog/A15468/
http://www.hmdb.ca/metabolites/HMDB29573
http://www.chemicalland21.com/industrialchem/organic/DIETHYL%20MALONATE.htm
Chemical Propertiescolourless liquid
Chemical PropertiesDiethyl malonate has a faint, pleasant, aromatic odor.
OccurrenceReported found in pineapple, bilberry, Cape gooseberry, cognac, malt whiskey, apple brandy, grape brandy, port, cider, sherry and red, white, strawberry and bilberry wines.
UsesDiethyl Malonate occurs naturally in grapes and strawberries. It is used in the preparation of barbiturates, artificial flavourings, vitamin B1, and vitamin B6 as well as in perfumes.
Usesmanufacture of barbiturates.
PreparationReacting chloroacetic acid to cyanoacetic acid using sodium cyanide and subsequent saponification; malonic acid is finally esterified by azeotropic distillation with ethanol in benzene
Taste threshold valuesTaste characteristics at 50 ppm: sweet and fruity with apple and pineapple nuances.
Safety ProfileMildly toxic by ingestion. A skin irritant. Combustible liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use water to blanket fire, foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.
Purification MethodsIf too impure (IR, NMR) the ester (250g) is heated on a steam bath for 36hours with absolute EtOH (125mL) and conc H2SO4 (75mL), then fractionally distilled under reduced pressure. Otherwise fractionally distil it under reduced pressure and collect the steady boiling middle fraction. [Beilstein 2 IV 1881.]
Diethyl malonate Preparation Products And Raw materials
Preparation Products2-HEXYLDECANOIC ACID-->CYCLOPENTYLACETIC ACID-->5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER-->Enoxacin-->Phenylbutazone-->4,6-Dichloro-2-(methylsulfonyl)pyrimidine-->2-BENZOFURANCARBOXYLIC ACID, ETHYL ESTER-->5-NITROBENZOFURAN-2-CARBOXYLIC ACID-->4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE-->Diethyl chloromalonate-->ETHYL 7-METHOXYBENZOFURAN-2-CARBOXYLATE-->5,7-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE-->2-Mercapto-4,6-dimethoxypyrimidine-->4-Chloro-6-methoxy-2-(methylthio)pyrimidine ,98%-->5,7-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE-->2-(TRIFLUOROMETHYL)-4-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID-->5-Nitropyridine-2-carboxylic acid-->2-ETHOXY-MALONIC ACID DIETHYL ESTER-->2,4-Dihydroxypyrimidine-5-carboxylic acid-->4,6-Dihydroxy-2-methylpyrimidine-->5,7-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID-->4-Chloro-7-(trifluoromethyl)quinoline-->ETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE-->4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER-->TRIETHYL 1,1,2-ETHANETRICARBOXYLATE-->ETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE-->2,4,5-Trifluorophenylacetic acid-->Gliclazide-->2-MERCAPTOPYRIMIDINE-4,6-DIOL-->ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE-->Diethyl butylmalonate-->2-AMINODIETHYLMALONATE-->2-amino-6-chloropyrimidin-4(3H)-one-->3-CARBETHOXYUMBELIFERONE-->DIETHYL 2-(2-CYANOETHYL)MALONATE-->5-CARBETHOXYURACIL-->3-CARBETHOXY-2-PIPERIDONE-->2-Amino-6-hydroxypyrimidin-4(3H)-one ,97%-->Sulfamonomethoxine
Raw materialsEtanol-->Hydrochloric acid-->Sulfuric acid -->Sodium carbonate-->Sodium cyanide-->Malonic acid-->Chloroacetic acid-->Chloroacetic acid sodium salt-->Cyanoacetic acid-->Disodium hydrogenorthophosphate-->MALONIC ACID DISODIUM SALT
Tag:Diethyl malonate(105-53-3) Related Product Information
Malonic acid Salicylaldehyde Diethyl malonate Trinexapac-ethyl Mefenpyr-diethyl Ethyl propionate Celiprolol ACETAMIDO DIETHYL MALONATE Etanol Diethyl ether Diethyl oxalate propanedioate 2-Ethoxyethanol Diethyl fluoromalonate Diethyl ethylmalonate Ethylene glycol diethyl ether Ethyl formate Ethyl acetate