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Actinomycin D

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CAS:50-76-0
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
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CAS:50-76-0
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Products Intro: Product Name:ActinoMycin D
CAS:50-76-0
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Actinomycin D Basic information
Product Name:Actinomycin D
Synonyms:1-ethanediyl)imino(2-(1-methylethyl)-carbonylimino(2-(1-hydroxyethyl)-1-oxo-;1-oxo-2,1-ethanediyl)-1,2-pyrrolidinediylcarbonyl(methylimino)(1-oxo-2,1-ethan;3h-phenoxazine-1,9-dicarboxamide,2-amino-n,n’-bis(hexadecahydro-2,5,9-trimethy;6-dimethyl-3-oxo-xatetra-azacyclohexadecin-10-yl)-;actd;actinomycin-(thre-val-pro-sar-meval);actinomycin11cosmegen;actinomycin7
CAS:50-76-0
MF:C62 H86 N12 O16
MW:1255.44
EINECS:232-485-1
Product Categories:Antibiotics;Antibiotic Explorer;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals;Caspases/Apoptosis;COSMEGEN;antibiotic
Mol File:50-76-0.mol
Actinomycin D Structure
Actinomycin D Chemical Properties
Melting point 251-253 °C
Boiling point 848°C (rough estimate)
density 1.0757 (rough estimate)
refractive index 1.5700 (estimate)
Fp 87℃
storage temp. 2-8°C
solubility ethanol, DMSO: Stable in aqueous solutions at 2-8 °C.soluble
form powder
color red, powder
Water Solubility SOLUBLE
Merck 13,2828
Stability:Stable, but light sensitive, especially in dilute solution. Incompatible with strong acids, strong bases, strong oxidizing agents. Combustible.
CAS DataBase Reference50-76-0(CAS DataBase Reference)
EPA Substance Registry SystemActinomycin D(50-76-0)
Safety Information
Hazard Codes T+
Risk Statements 28-61-40-45-26/27/28
Safety Statements 53-36/37/39-45-1-36/37-28-22
RIDADR UN 3462 6.1/PG 2
WGK Germany 3
RTECS AU1575000
8-10-21
HazardClass 6.1(a)
PackingGroup II
HS Code 29419000
Hazardous Substances Data50-76-0(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Actinomycin D English
SigmaAldrich English
Actinomycin D Usage And Synthesis
Chemical Propertiesred crystalline powder
UsesAn antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent.
Usesantineoplastic, intercalating agent
UsesActinomycin D is the most studied member of a family of unique bicyclic depsipeptides produced by several Streptomyces species. The depsipeptides are linked by a heterocyclic benzoxazone "anchor" that gives the metabolites a highly distinctive red/orange colour. Actinomycin D exhibits potent antibiotic and antitumour activity via DNA intercalation leading to the inhibition of nucleic acid synthesis. Tumour cell death has been demonstrated to occur by apoptosis.
UsesActinomycin D is the most studied member of a family of unique bicyclic depsipeptides produced by several Streptomyces species. The depsipeptides are linked by a heterocyclic benzoxazone "anchor" that gives the metabolites a highly distinctive red/orange colour. Actinomycin D exhibits potent antibiotic and antitumor activity via DNA intercalation leading to the inhibition of nucleic acid synthesis. Tumor cell death has been demonstrated to occur by apoptosis.
UsesAntibiotic substance belonging to the actinomycin complex, produced by several Streptomyces spp. Antineoplastic
Brand nameCosmegen (Ovation).
General DescriptionBright red rhomboid prisms or red powder.
Air & Water ReactionsWater soluble.
Reactivity ProfileActinomycin D can react with strong oxidizing agents, strong acids and strong bases.
Fire HazardFlash point data for Actinomycin D are not available. Actinomycin D is probably combustible.
Biological ActivityAnti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.
Purification MethodsIt crystallises as bright red rhombic crystals from absolute EtOH or from MeOH/EtOH (1:3). It will also crystallise from EtOAc/cyclohexane (m 246-247o dec), CHCl3/pet ether ( m 245-246o dec), and EtOAc/MeOH/*C6H6 (m 241-243o dec). Its solubility in MeCN is 1mg/mL. [] D varies from -296o to -327o (c 0.2, MeOH). max (MeOH) 445, 240nm (log  4.43, 4.49), max (MeOH, 10N HCl, 1:1) 477nm (log  4.21) and max (MeOH, 0.1N NaOH) 458, 344, 285 (log  3.05, 4.28, 4.13). It is HIGHLY TOXIC, light sensitive and anti-neoplastic. [Bullock & Johnson, J Chem Soc 3280 1957, Beilstein 27 III/IV 9642.]
Actinomycin D Preparation Products And Raw materials
Raw materialsAluminum oxide -->streptomyces avermifilis-->Sepia (dye)
Tag:Actinomycin D(50-76-0) Related Product Information
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) N-BUTYLISOCYANIDE TERT-BUTYL ISOCYANIDE Tosylmethyl isocyanide SALCOMINE Aluminum acetylacetonate ACTINOMYCIN E2,ACTINOMYCIN E2 Actinomycin VI,Actinomycin VI 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Actinomycin D Tris Base actinomycin,actinomycin Glycine AMINO ACIDS 6-Aminocaproic acid 3-Aminophenol Actidione streptomyces avermifilis