| Company Name: |
Chengdu Kamel Pharmaceutical Co., Ltd
|
| Tel: |
028-67136579 15828051124 |
| Email: |
sales@kamelpharm.com |
| Products Intro: |
Product Name:Tiaramide
CAS:32527-55-2
Purity:98% Package:1g/;10g/;100g/;1000g/ Remarks:001851
|
| Company Name: |
Bide Pharmatech Ltd.
|
| Tel: |
400-1647117 15221909166 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:Tiaramide
CAS:32527-55-2
Purity:95% Package:100mg;250mg;1g; Remarks:BD154095
|
Tiaramide manufacturers
- Tiaramide
-
- $1.00 / 1g
-
2021-07-20
- CAS:32527-55-2
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 50tons
- Tiaramide USP/EP/BP
-
- $1.10 / 1g
-
2021-06-17
- CAS:32527-55-2
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
|
| | Tiaramide Basic information |
| Product Name: | Tiaramide | | Synonyms: | 1-Piperazineethanol, 4-((5-chloro-2-oxo-3(2H)-benzothiazolyl)acetyl)- (9ci);1-Piperazineethanol, 4-((5-chloro-2-oxo-3-benzothiazolinyl)acetyl)-;35941-71-0 (Mono-hydrochloride);4-((5-Chloro-2-oxo-3(2H)-benzothiazolyl)acetyl)-1-piperazineethanol;5-Chlor-2,3-dihydro-3-(4-(2-hydroxyethyl)piperazinylcarbonylmethyl)-2-benzothiazolon;Brn 1030245;Einecs 251-083-7;Rhc 2592a | | CAS: | 32527-55-2 | | MF: | C15H18ClN3O3S | | MW: | 355.84 | | EINECS: | 251-083-7 | | Product Categories: | | | Mol File: | 32527-55-2.mol |  |
| | Tiaramide Chemical Properties |
| Melting point | 159-161 °C | | Boiling point | 605.8±65.0 °C(Predicted) | | density | 1.432±0.06 g/cm3(Predicted) | | pka | 6.2(at 25℃) |
| | Tiaramide Usage And Synthesis |
| Originator | Solantal,Fujisawa,Japan,1975 | | Definition | ChEBI: Tiaramide is a member of benzothiazoles. | | Manufacturing Process | A solution of ethyl 5-chloro-2-oxo-3-benzo-thiazolineacetate (4.0 grams) in 1-
(2-hydroxyethyl)piperazine is heated at 100°C for 24 hours. After cooling, the
resulting mixture is extracted with chloroform. The chloroform extract is
washed with water and shaken with 10% hydrochloric acid. The hydrochloric
acid layer is washed with chloroform, made alkaline with 10% sodium
hydroxide solution and extracted with chloroform. The chloroform extract is
washed with water, dried over magnesium sulfate and concentrated. The
residual oil (5.5 grams) is allowed to stand to form crystals, which are
recrystallized from a mixture of ethyl acetate (40 ml) and ethanol (15 ml) to
give 3-[4-(2-hydroxyethyl)-1-piperazinylcarbonylmethyl]-5-chloro-2(3H)-
benzothiazolinone (3.2 grams) as colorless crystals, MP 159° to 161°C.
The following is an alternate method of preparation: A mixture of 3-(1-
piperazinyl)carbonylmethyl-5-chloro-2(3H)-benzothiazolinone (500 mg),
anhydrous potassium carbonate (400 mg), 2-hydroxyethyl bromide (300 mg)
and anhydrous ethanol (20 ml) is heated while refluxing for 5 hours. The
reaction mixture is concentrated under reduced pressure. The residue is
extracted with chloroform. The chloroform layer is dried over magnesium
sulfate and concentrated. The residue is crystallized from a mixture of ethyl
acetate and ethanol to give 3-[4-(2-hydroxyethyl]-1-
piperazinylcarbonylmethyl]-5-chloro-2(3H)-benzothiazolinone (370 mg) as
crystals, MP 159° to 160°C. | | Therapeutic Function | Antiinflammatory |
| | Tiaramide Preparation Products And Raw materials |
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