| Company Name: |
Ralington Pharma
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| Tel: |
+91-7948911722 +91-9687771722 |
| Email: |
info@ralingtonpharma.com |
| Products Intro: |
Product Name:Betamethasone 21-phosphate
CAS:360-63-4
Purity:98% Package:1 kg,5 kg, 10 kg,25kg and 1 MT
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| Company Name: |
Shanghai T&W Pharmaceutical Co., Ltd.
|
| Tel: |
+86 21 61551611 |
| Email: |
|
| Products Intro: |
Product Name:BETAMETHASONE SODIUM PHOSPHATE
CAS:360-63-4
Purity:98% Package:50kg;25kg;10kg;5kg;500g;500mg;
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| | Dexamethasone sodium phosphate EP Impurity B Basic information |
| Product Name: | Dexamethasone sodium phosphate EP Impurity B | | Synonyms: | 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-(hydrogen phosphonate);Betamethasone phosphate;Betamethasone 21-(dihydrogen phosphate);Betamethasone 21-phosphate;Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11β,16β)- (9CI);Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 21-(dihydrogen phosphate) (7CI, 8CI);9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-phosphate;9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-phosphoric acid | | CAS: | 360-63-4 | | MF: | C22H30FO8P | | MW: | 472.44 | | EINECS: | 206-636-7 | | Product Categories: | | | Mol File: | 360-63-4.mol |  |
| | Dexamethasone sodium phosphate EP Impurity B Chemical Properties |
| | Dexamethasone sodium phosphate EP Impurity B Usage And Synthesis |
| Originator | Bentelan,Biofutura | | Uses | Glucocorticoid. | | Definition | ChEBI: Betamethasone phosphate is a steroid phosphate that is the 21-O-phospho derivative of betamethasone. It has a role as an anti-inflammatory agent and an immunosuppressive agent. It is a steroid phosphate, an 11beta-hydroxy steroid, a fluorinated steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a betamethasone. It is a conjugate acid of a betamethasone phosphate(2-). | | Manufacturing Process | A solution of bistriethylamine phosphate was prepared by slowly adding 2.36
ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml, of
triethylamine at 20°C. This solution was added to a stirred mixture of 4.70 g
of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione
21-methanesulfonate and 20 ml of acetonitrile. The mixture was heated under
reflux for 4 h and then evaporated under reduced pressure to a volume of 12
ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21-
trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate
triethylamine salt with some inorganic phosphate.
The salt of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-
3,20-dione 21-phosphate may be converted to 9α-fluoro-11β,17α,21-
trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate by
treatment with acid (for example HCl). | | Brand name | Celestone (Schering). | | Therapeutic Function | Glucocorticoid |
| | Dexamethasone sodium phosphate EP Impurity B Preparation Products And Raw materials |
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