库美香豆素
| 中文名称 | 库美香豆素 |
|---|---|
| 中文同义词 | 库美香豆素;库美香豆素,双香豆素醚;化合物 T10867 |
| 英文名称 | coumetarol |
| 英文同义词 | Cumetharol;3,3'-(2-Methoxyethylidene)bis(4-hydroxycoumarin);Cumethoxethan;Dicoumoxyl;Dicumoxane;2-hydroxy-3-[1-(2-hydroxy-4-keto-chromen-3-yl)-2-methoxy-ethyl]chromone;2-hydroxy-3-[1-(2-hydroxy-4-oxo-chromen-3-yl)-2-methoxy-ethyl]chromen-4-one;2-hydroxy-3-[1-(2-hydroxy-4-oxochromen-3-yl)-2-methoxyethyl]chromen-4-one |
| CAS号 | 4366-18-1 |
| 分子式 | C21H16O7 |
| 分子量 | 380.35 |
| EINECS号 | 2244551 |
| 相关类别 | |
| Mol文件 | 4366-18-1.mol |
| 结构式 |  |
库美香豆素 性质
| 熔点 | 156-157° |
|---|---|
| 沸点 | 639.9±55.0 °C(Predicted) |
| 密度 | 1.514±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 4.20±1.00(Predicted) |
Coumetarol (Dicumoxane) 是维生素 K 拮抗剂。
vitamin K
Coumetarol (Dicumoxane), an oral anticoagulant, is active in both models. The vitamin K antagonist Coumetarol is effective in both models after oral treatment but inhibits the thrombus formation more strongly in the arterio-venous shunt model. Treatment with the vitamin K antagonist Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments the coagulation time as measured by the Thrombotest is prolonged to the same extent.
安全信息
| 危险品运输编号 | 2811 |
|---|---|
| 危险等级 | 6.1(b) |
| 包装类别 | III |