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BTO-1

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BTO-1 Suppliers list
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:BTO-1
CAS:40647-02-7
Purity:>=97% Package:$114.9/2mg;Bulk package Remarks:97%
Company Name: Sigma-Aldrich  
Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Products Intro: Product Name:BTO-1
CAS:40647-02-7
Purity:>=98% (HPLC), solid Package:5MG Remarks:B6311-5MG
Company Name: Shanghai Aladdin Biochemical Technology Co.,Ltd.  
Tel: +86-18521732826
Email: market@aladdin-e.com
Products Intro: Product Name:BTO-1
CAS:40647-02-7
Purity:>=97% Package:2mg/RMB 838.90
Company Name: CLEARSYNTH LABS LTD.  
Tel: +91-22-45045900
Email: sales@clearsynth.com
Products Intro: Product Name:BTO-1
CAS:40647-02-7
Company Name: United States Biological  
Tel: 800.520.3011 or 781.639.5092
Email: chemicals@usbio.net
Products Intro: Product Name:BTO-1
CAS:40647-02-7
BTO-1 Basic information
Product Name:BTO-1
Synonyms:BTO-1;5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide;Polo-like Kinase Inhibitor II, BTO-1;Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem;2-Benzothiazolecarboxamide, 5-cyano-7-nitro-, 3-oxide
CAS:40647-02-7
MF:C9H4N4O4S
MW:264.22
EINECS:
Product Categories:
Mol File:40647-02-7.mol
BTO-1 Structure
BTO-1 Chemical Properties
Boiling point 553.0±60.0 °C(Predicted)
density 1.89±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility H2O: <2ML/mL
pka14.67±0.30(Predicted)
form solid
color tan
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36/37
WGK Germany 3
MSDS Information
BTO-1 Usage And Synthesis
UsesBTO-1 is a benzothiazolo-N-oxide Plk1 inhibitor.
General DescriptionA cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC50 = 8.0 μM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 μM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of γ-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring.
Biochem/physiol ActionsBTO-1 is a polo-like kinase (Plk) inhibitor.
BTO-1 Preparation Products And Raw materials
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