| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:BTO-1
CAS:40647-02-7
Purity:>=97% Remarks:Reach out to us for more information about custom solutions.
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:BTO-1
CAS:40647-02-7
Purity:>=98% (HPLC), solid Package:5MG Remarks:B6311-5MG
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:BTO-1
CAS:40647-02-7
Package:25mg/RMB 10600
|
|
| Product Name: | BTO-1 | | Synonyms: | BTO-1;5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide;Polo-like Kinase Inhibitor II, BTO-1;Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem;2-Benzothiazolecarboxamide, 5-cyano-7-nitro-, 3-oxide | | CAS: | 40647-02-7 | | MF: | C9H4N4O4S | | MW: | 264.22 | | EINECS: | | | Product Categories: | | | Mol File: | 40647-02-7.mol |  |
| | BTO-1 Chemical Properties |
| Boiling point | 553.0±60.0 °C(Predicted) | | density | 1.89±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | H2O: <2ML/mL | | pka | 14.67±0.30(Predicted) | | form | solid | | color | tan | | Water Solubility | H2O: <2mL/mL
DMSO: ≥5mg/mL |
| | BTO-1 Usage And Synthesis |
| Uses | BTO-1 is a benzothiazolo-N-oxide Plk1 inhibitor. | | General Description | A cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC50 = 8.0 μM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 μM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of γ-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring. | | Biochem/physiol Actions | BTO-1 is a polo-like kinase (Plk) inhibitor. |
| | BTO-1 Preparation Products And Raw materials |
|