| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:JNJ-7925476 free base
CAS:129540-12-1
Package:50mg/RMB 13800;100mg/RMB 17500;25mg/RMB 10600
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Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) manufacturers
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| | Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) Basic information |
| Product Name: | Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) | | Synonyms: | Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI);JNJ-7925476 free base;JNJ7925476 free base,JNJ 7925476 free base | | CAS: | 129540-12-1 | | MF: | C20H19N | | MW: | 273.37 | | EINECS: | | | Product Categories: | | | Mol File: | 129540-12-1.mol | ![Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) Structure](CAS/20210305/GIF/129540-12-1.gif) |
| | Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) Chemical Properties |
| Boiling point | 403.3±33.0 °C(Predicted) | | density | 1.16±0.1 g/cm3(Predicted) | | pka | 8.35±0.40(Predicted) |
| | Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) Usage And Synthesis |
| Uses | JNJ-7925476 is a triple reuptake inhibitor that selectively and potently inhibits the activity of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT). JNJ-7925476 is rapidly absorbed into the blood and its concentration in the brain is 7-fold higher than that in plasma. The occupancy ED(50) values of JNJ-7925476 for SERT, NET, and DAT in the rat brain are 0.18, 0.09, and 2.4 mg/kg, respectively. JNJ-7925476 rapidly induces a significant increase in the levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex in a dose-dependent manner. JNJ-7925476 exhibits potent antidepressant-like activity in the mouse tail suspension test. These results suggest that JNJ-7925476 has in vivo efficacy in biochemical and behavioral models of depression[1]. | | References | [1] In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor DOI:10.1016/j.ejphar.2008.04.008 |
| | Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) Preparation Products And Raw materials |
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