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| | 5-BROMOMETHYL-1,2,3-TRIMETHOXY-BENZENE Basic information |
| | 5-BROMOMETHYL-1,2,3-TRIMETHOXY-BENZENE Chemical Properties |
| Melting point | 74-75 °C | | Boiling point | 306.5±37.0 °C(Predicted) | | density | 1.367±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| | 5-BROMOMETHYL-1,2,3-TRIMETHOXY-BENZENE Usage And Synthesis |
| Uses | 5-(Bromomethyl)-1,2,3-trimethoxybenzene is a useful reactant for the preparation of carbolines. | | Synthesis | General method: 3,4,5-trimethoxybenzyl alcohol (1 mmol) was dissolved in anhydrous benzene (15 mL), phosphorus tribromide (0.5 mL) was added and the reaction was stirred at room temperature. Upon completion of the reaction, 3,4,5-trimethoxybenzyl bromide was obtained in quantitative yield by a conventional post-treatment step. | | References | [1] Journal of Steroid Biochemistry and Molecular Biology, 2013, vol. 137, p. 332 - 344
[2] Chemistry - A European Journal, 2015, vol. 21, # 28, p. 10031 - 10038
[3] Medicinal Chemistry Research, 2015, vol. 24, # 8, p. 3143 - 3156
[4] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 5, p. 1630 - 1642
[5] Synthetic Communications, 1987, vol. 17, # 7, p. 877 - 892 |
| | 5-BROMOMETHYL-1,2,3-TRIMETHOXY-BENZENE Preparation Products And Raw materials |
| Raw materials | 5-(Chloromethyl)-1,2,3-trimethoxybenzene-->3,4,5-Trimethoxybenzyl alcohol-->Methyl 3,4,5-trimethoxybenzoate-->Gallic acid-->3,4,5-Trimethoxytoluene-->3,4,5-Trimethoxy benzoic acid-->3,4,5-Trimethoxybenzaldehyde-->1H-Imidazolium, 1,3-dimethyl-2-[[(3,4,5-trimethoxyphenyl)methyl]thio]-, 1,1,1-trifluoromethanesulfonate (1:1)-->Benzene-->Phosphorus tribromide |
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