ChemicalBook > Product Catalog >Organic Chemistry >Organosilicon compounds >Hexamethyldisilazane

Hexamethyldisilazane

Hexamethyldisilazane Suppliers list
Company Name: Jiangxi New jiayi New Materials Co., Ltd.
Tel: 15988280056
Email: info@xjysi.com; mina@xjysi.com
Products Intro: Product Name:Hexamethyldisilazane; 1,1,1,3,3,3-HEXAMETHYLDISILAZANE; HMDZ
CAS:999-97-3
Purity:99% Package:200L drum Remarks:Hexamethyldisilazane; 1,1,1,3,3,3-HEXAMETHYLDISILAZANE; HMDZ
Company Name: Ningxia Jinhua Chemical Co.,Ltd
Tel: 025-52279164
Email: info@nxjhchem.com
Products Intro: Product Name:Hexamethyldisilazane(HMDS)
CAS:999-97-3
Purity:99% Package:25Kg/Drum;USD
Company Name: Foshan Sanshui Jingze Chemical Co.,Ltd
Tel: 025-86639253
Email: sales@jingze-chem.com
Products Intro: Product Name:Hexamethyldisilazane(HMDS)
CAS:999-97-3
Purity:99% Package:25Kg/Bag;USD
Company Name: Quzhou dongye chemical technology co., ltd
Tel: 13957006720
Email: sales@dm-chem.com
Products Intro: Product Name:Hexamethyldisilazane;HMDS >=99%
CAS:999-97-3
Purity:>=99% Package:25g;USD|50g;USD|100g;USD|1KG;USD|5KG;USD
Company Name: Neostar United (Changzhou) Industrial Co., Ltd.
Tel: +0086-519-85557386
Email: marketing1@neostarunited.com
Products Intro: Product Name:Hexamethyldisilazane
CAS:999-97-3
Package:As requirement

Hexamethyldisilazane manufacturers

  • Hexamethyldisilazane
  • $0.00 / Kg/Drum
  • 2022-01-26
  • CAS:999-97-3
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 2000mt/year
  • Hexamethyldisilazane
  • $1.70 / Kg/Drum
  • 2021-12-01
  • CAS:999-97-3
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 10000kg
  • Hexamethyldisilazane
  • $20.00 / KG
  • 2021-11-30
  • CAS:999-97-3
  • Min. Order: 1T
  • Purity: 99%
  • Supply Ability: 1000T

Related articles

Hexamethyldisilazane Chemical Properties
Melting point -78 °C
Boiling point 125 °C (lit.)
density 0.774 g/mL at 25 °C(lit.)
vapor density 4.6 (vs air)
vapor pressure 20 hPa (20 °C)
refractive index n20/D 1.407(lit.)
Fp 57.2 °F
storage temp. Store below +30°C.
solubility Miscible with acetone, benzene, ethyl ether, heptane and perchloroethylene.
pka30(at 25℃)
form Liquid
color Colorless
Specific Gravity0.774
OdorAmmonia odour
PH Range8.5
explosive limit0.8-25.9%(V)
Water Solubility REACTS
Sensitive Moisture Sensitive
Hydrolytic Sensitivity7: reacts slowly with moisture/water
Merck 14,4689
BRN 635752
InChIKeyFFUAGWLWBBFQJT-UHFFFAOYSA-N
CAS DataBase Reference999-97-3(CAS DataBase Reference)
NIST Chemistry ReferenceSilanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-(999-97-3)
EPA Substance Registry SystemHexamethyldisilazane (999-97-3)
Safety Information
Hazard Codes F,C,Xn
Risk Statements 11-20/21/22-34-52/53
Safety Statements 16-26-36/37/39-45-61
RIDADR UN 3286 3/PG 2
WGK Germany 2
RTECS JM9230000
21
Autoignition Temperature325 °C
Hazard Note Flammable
TSCA Yes
HS Code 2931 90 00
HazardClass 3
PackingGroup II
Hazardous Substances Data999-97-3(Hazardous Substances Data)
ToxicityLDLO i.p. in mice: 650 mg/kg (Petrarch Systems Inc. Product Information Sheets)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Hexamethyldisilazane Usage And Synthesis
ReactionHexamethyldisilazane(HMDS) is an extremely versatile and strong silylating agent. It is primarily used for the protection of sensitive functional groups during chemical synthesis.One of the advantages of Hexamethyldisilazane over chlorosilanes is that no base is needed as a hydrochloric acid acceptor. It produces ammonia which escapes easily from the reaction mixture during silylation.
DescriptionHexamethyldisilazane is a bulk organo silicon compound, being a quite useful silanizing agent. It is a reagent for the preparation of trimethylsilyl derivatives. It can be used for silanizing the surface of silicon water, cellulose. It can also be used to dehydrate cells of biomaterials for scanning electron microscopy (SEM). The hexamethyldisilazane coatings on various nanoparticles make them be resistant to water contamination and flocculation during synthesis. It can also be used as a modifier to control the shape, formation of agglomerates surface area and pore size of silica particles. Moreover, it is an adhesion promoter for photoresist in photolithography, and is also useful in the pyrolysis-gas chromatography-mass spectrometry to enhance the detectability of compounds with polar functional groups.
Chemical PropertiesColorless liquid
Physical propertiesbp 125 °C; d 0.765 g cm?3.
UsesDeactivation of chromatographic support materials. In electronic industry as an adhesion promoter for photoresists on silicon.
UsesHexamethyldisilazane mainly used as methyl silane alkylation (such as amikacin, penicillin, cephalosporins and kinds of penicillin derivatives), hydroxyl protectants of antibiotics. It is used as surface treatment agent of diatomite, white carbon black, titanium and blond additives of photoresist in the semiconductor industry. It is used as treatment agent of tearing strength resistance. It is used as a solvent in organic synthesis and organometallic chemistry. It is used as an adhesion promoter for photoresist in photolithography. it is used for the preparation of trimethylsilyl ethers from hydroxy compounds. It is used as an alternative to critical point drying during sample preparation in electron microscopy. It is added to analyte to get silylated diagnostic products during pyrolysis in gas chromatography- mass spectrometry.
UsesA reagent for the preparation of trimethylsilyl derivatives.
DefinitionChEBI: An N-silyl compound obtained from ammonia by replacement of two of the hydrogens with trimethylsilyl groups. Hexamethyldisilazane is a derivatisation agent used in gas chromatography mass spectrometry applications.
General DescriptionA liquid. Boiling point of 260°F. Flash point 77°F. May be toxic by ingestion. Irritates skin and eyes. Vapors are heavier than air. May emit highly toxic nitrogen oxide fumes when heated to decomposition. Used to make other chemicals.
Air & Water ReactionsHighly flammable. Moisture sensitive.
Reactivity ProfileHexamethyldisilazane reacts with many carbonyl containing organic compounds to generate gaseous ammonia. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
HazardFlammable, moderate fire risk.
Health HazardInhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Purification MethodsA possible impurity is Me3SiCl. Wash it well with pet ether and fractionate it through a vacuum jacketed column packed with Helipac using a reflux ratio of 10:1. [Langer et al. J Org Chem 23 50 1958, Beilstein 4 IV 4014.]
ReferencesDeng, Xiang. "Hexamethyldisilazane." Synlett 2011.06(2011):881-882. Chiavari, G, D. Fabbri, and S. Prati. "Gas chromatographic-mass spectrometric analysis of products arising from pyrolysis of amino acids in the presence of hexamethyldisilazane." Journal of Chromatography A922.1–2(2001):235-241.
Nation, J. L. "A new method using hexamethyldisilazane for preparation of soft insect tissues for scanning electron microscopy." Stain Technology 58.6(1983):347-51.
http://www.sigmaaldrich.com/catalog/product/sial/52619? lang=en®ion=US
http://www.sigmaaldrich.com/catalog/product/aldrich/40215? lang=en®ion=US
http://www.sigmaaldrich.com/catalog/product/sial/86944? lang=en®ion=US
Tag:Hexamethyldisilazane(999-97-3) Related Product Information
Hexamethyldisilane 1,3,5-triazine-2,4,6-triyltrinitrilohexamethanol 3-Glycidoxypropyltrimethoxysilane 3-Aminopropyltriethoxysilane Hexamethyldisiloxane Hexamethylcyclotrisiloxane Potassium bis(trimethylsilyl)amide N,N-Bis(trimethylsilyl)formamide NONAMETHYLSTANNASILAZANE 1,3-DI-N-OCTYLTETRAMETHYLDISILAZANE (1-ETHOXYCARBONYLMETHYL)-2,2,5,5-TETRAMETHYL-1-AZA-2,5-DISILACYCLOPENTANE HEPTAMETHYLDISILAZANE BIS(TRIMETHYLSILYL)AMIDODIMETHYLPHOSPHINE N,N-Bis(trimethylsilyl)acetamide 1,3-DIVINYL-1,3-DIPHENYL-1,3-DIMETHYLDISILAZANE 1,3-DIPHENYL-1,1,3,3-TETRAMETHYLDISILAZANE 1,3-BIS(CHLOROMETHYL)TETRAMETHYLDISILAZANE 1,3-DIMETHYL-1,1,3,3-TETRAPHENYLDISILAZANE