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| | Carbamic acid, cyclopropyl-, 1,1-dimethylethyl ester (9CI) Basic information |
| Product Name: | Carbamic acid, cyclopropyl-, 1,1-dimethylethyl ester (9CI) | | Synonyms: | Carbamic acid, cyclopropyl-, 1,1-dimethylethyl ester (9CI);N-Boc-cyclopropylamine;Cyclopropylamine, N-BOC protected;tert-Butyl cyclopropylcarbamate;REF DUPL: N-Boc-cyclopropylamine;CarbaMic acid, cyclopropyl-, 1,1-diMethylethyl ester;tert-butyl N-cyclopropylcarbaMate;Cyclopropylcarbamic acid tert-butyl ester | | CAS: | 132844-48-5 | | MF: | C8H15NO2 | | MW: | 157.21 | | EINECS: | | | Product Categories: | Ring Systems;N-BOC;Amines | | Mol File: | 132844-48-5.mol |  |
| | Carbamic acid, cyclopropyl-, 1,1-dimethylethyl ester (9CI) Chemical Properties |
| Melting point | 62-64° | | Boiling point | 228.6±7.0 °C(Predicted) | | density | 1.01±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 12.74±0.20(Predicted) | | Appearance | White to off-white Solid |
| | Carbamic acid, cyclopropyl-, 1,1-dimethylethyl ester (9CI) Usage And Synthesis |
| Synthesis | Step 1. Dissolve cyclopropylamine (12.4 g, 252.2 mmol) in dichloromethane (50 mL) at 0°C and cool in an ice water bath. A solution of di-tert-butyl dicarbonate (43.7 g, 200 mmol) in dichloromethane (100 mL) was slowly added dropwise. After the dropwise addition, the reaction mixture was transferred to room temperature and stirred continuously for 18 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation to afford N-Boc-cyclopropylamine (31 g, 99% yield). | | References | [1] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2213 - 2236
[2] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 6, p. 1527 - 1536
[3] Patent: US2007/225280, 2007, A1. Location in patent: Page/Page column 17
[4] Monatshefte fur Chemie, 2017, vol. 148, # 12, p. 2143 - 2153
[5] Organic Letters, 2012, vol. 14, # 17, p. 4458 - 4461 |
| | Carbamic acid, cyclopropyl-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials |
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