净特罗
| 中文名称 | 净特罗 |
|---|---|
| 中文同义词 | 净特罗;化合物 T13399 |
| 英文名称 | N-(2-HYDROXY-5-(1-HYDROXY-2-(2-METHYL-1-PHENYLPROPAN-2-YLAMINO)ETHYL)PHENYL)METHANE |
| 英文同义词 | Zinterol;N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamidehydrochloride;N-{5-[2-(1,1-DiMethyl-2-phenyl-ethylaMino)-1-hydroxy-ethyl]-2-hydroxy-phenyl}-MethaesulfonaMide;MJ 9184;Methanesulfonamide, N-[5-[2-[(1,1-dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]-;Zinterol hydrochlori |
| CAS号 | 37000-20-7 |
| 分子式 | C19H26N2O4S |
| 分子量 | 378.49 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 37000-20-7.mol |
| 结构式 |  |
净特罗 性质
| 沸点 | 574.3±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.282±0.06 g/cm3(Predicted) |
| 储存条件 | Store at +4°C |
| 溶解度 | 在水中溶解度为 5 mM，在 DMSO 中溶解度为 100 mM |
| 形态 | 粉末 |
| 酸度系数(pKa) | 8.57±0.50(Predicted) |
Zinterol (MJ 9184) 是一种有效的选择性 β2-肾上腺素受体 (β2-adrenoceptor) 激动剂。Zinterol 增强 ICa，EC50 为 2.2 nM。
β2-adrenoceptor
Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits.
| Animal Model: | In New Zealand White HF rabbits of either sex |
| Dosage: | 1.0 or 2.5 μg/kg |
| Administration: | Intravenous bolus administration; over 5 seconds |
| Result: |
2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits.
2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2023/03/20 | HY-14304 | 净特罗 Zinterol | 37000-20-7 | 1mg | 1550元 |
| 2023/03/20 | HY-14304 | 净特罗 Zinterol | 37000-20-7 | 10mM * 1mLin DMSO | 3872元 |