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1H-Isoindole-1,3(2H)-dione, 4-[[15-[4-[5-[6-amino-5-[[3-(3-hydroxy-3-methyl-1-butyn-1-yl)phenyl]methoxy]-3-pyridinyl]-2-thiazolyl]-1-piperidinyl]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]oxy]-2-(2,6-dioxo-3-piperidinyl)-

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1H-Isoindole-1,3(2H)-dione, 4-[[15-[4-[5-[6-amino-5-[[3-(3-hydroxy-3-methyl-1-butyn-1-yl)phenyl]methoxy]-3-pyridinyl]-2-thiazolyl]-1-piperidinyl]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]oxy]-2-(2,6-dioxo-3-piperidinyl)- Suppliers list
Company Name: Suzhou ARTK Medchem Co., Ltd.
Tel: +86-512-68323658 +86-18168183658
Email: sales1@artkmedchem.com
Products Intro: Product Name:4-[2-[2-[2-[2-[3-[4-[5-[6-amino-5-[[3-(3-hydroxy-3-methyl-but-1-ynyl)phenyl]methoxy]-3-pyridyl]thiazol-2-yl]-1-piperidyl]-3-oxo-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
CAS:2636072-62-1
Purity:0.98 Package:100KG;25KG;10KG;1KG
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:SS47
CAS:2636072-62-1
Purity:98%+HPLC Package:10mg，100mg，500mg，1g，2g，5g，10g，More
Company Name: PharmaBlock Sciences (Nanjing), Inc.  
Tel: 4000255188 4000255188
Email: sales@pharmablock.com
Products Intro: Product Name:4-[2-[2-[2-[2-[3-[4-[5-[6-amino-5-[[3-(3-hydroxy-3-methyl-but-1-ynyl)phenyl]methoxy]-3-pyridyl]thiazol-2-yl]-1-piperidyl]-3-oxo-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
CAS:2636072-62-1
Purity:97% Package:1G;5G;10G;100G;250G
1H-Isoindole-1,3(2H)-dione, 4-[[15-[4-[5-[6-amino-5-[[3-(3-hydroxy-3-methyl-1-butyn-1-yl)phenyl]methoxy]-3-pyridinyl]-2-thiazolyl]-1-piperidinyl]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]oxy]-2-(2,6-dioxo-3-piperidinyl)- Basic information
Product Name:1H-Isoindole-1,3(2H)-dione, 4-[[15-[4-[5-[6-amino-5-[[3-(3-hydroxy-3-methyl-1-butyn-1-yl)phenyl]methoxy]-3-pyridinyl]-2-thiazolyl]-1-piperidinyl]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]oxy]-2-(2,6-dioxo-3-piperidinyl)-
Synonyms:1H-Isoindole-1,3(2H)-dione, 4-[[15-[4-[5-[6-amino-5-[[3-(3-hydroxy-3-methyl-1-butyn-1-yl)phenyl]methoxy]-3-pyridinyl]-2-thiazolyl]-1-piperidinyl]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]oxy]-2-(2,6-dioxo-3-piperidinyl)-;4-[2-[2-[2-[2-[3-[4-[5-[6-amino-5-[[3-(3-hydroxy-3-methyl-but-1-ynyl)phenyl]methoxy]-3-pyridyl]thiazol-2-yl]-1-piperidyl]-3-oxo-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;SS47
CAS:2636072-62-1
MF:C49H56N6O12S
MW:953.07
EINECS:
Product Categories:
Mol File:2636072-62-1.mol
1H-Isoindole-1,3(2H)-dione, 4-[[15-[4-[5-[6-amino-5-[[3-(3-hydroxy-3-methyl-1-butyn-1-yl)phenyl]methoxy]-3-pyridinyl]-2-thiazolyl]-1-piperidinyl]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]oxy]-2-(2,6-dioxo-3-piperidinyl)- Structure
1H-Isoindole-1,3(2H)-dione, 4-[[15-[4-[5-[6-amino-5-[[3-(3-hydroxy-3-methyl-1-butyn-1-yl)phenyl]methoxy]-3-pyridinyl]-2-thiazolyl]-1-piperidinyl]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]oxy]-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties
Boiling point 1097.5±65.0 °C(Predicted)
density 1.40±0.1 g/cm3(Predicted)
pka10.70±0.40(Predicted)
Safety Information
MSDS Information
1H-Isoindole-1,3(2H)-dione, 4-[[15-[4-[5-[6-amino-5-[[3-(3-hydroxy-3-methyl-1-butyn-1-yl)phenyl]methoxy]-3-pyridinyl]-2-thiazolyl]-1-piperidinyl]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]oxy]-2-(2,6-dioxo-3-piperidinyl)- Usage And Synthesis
UsesSS47, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the antitumor efficacy[1].
in vivo

SS47 (10 mg/kg, Subcutaneous injection, once a day for 10 days from day 5) can degrade HPK1 in 4T-1 tumor-bearing mice[1].

Animal Model:4T-1 tumor-bearing mice[1]
Dosage:10 mg/kg
Administration:Subcutaneous injection (s.c.)
Result:Exerted protea-some-mediated HPK1 degradation within 48 h.
IC 50HPK1
References[1] Si J, et al. Hematopoietic progenitor kinase1 (HPK1) mediates T cell dysfunction and is a druggable target for T cell-based immunotherapies [J]. Cancer Cell, 2020, 38(4): 551-566. e11. DOI:10.1016/j.ccell.2020.08.001
1H-Isoindole-1,3(2H)-dione, 4-[[15-[4-[5-[6-amino-5-[[3-(3-hydroxy-3-methyl-1-butyn-1-yl)phenyl]methoxy]-3-pyridinyl]-2-thiazolyl]-1-piperidinyl]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]oxy]-2-(2,6-dioxo-3-piperidinyl)- Preparation Products And Raw materials
Tag:1H-Isoindole-1,3(2H)-dione, 4-[[15-[4-[5-[6-amino-5-[[3-(3-hydroxy-3-methyl-1-butyn-1-yl)phenyl]methoxy]-3-pyridinyl]-2-thiazolyl]-1-piperidinyl]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]oxy]-2-(2,6-dioxo-3-piperidinyl)-(2636072-62-1) Related Product Information
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