| Company Name: |
Hubei Xinyang Medical Technology Co., Ltd
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| Tel: |
15347293736 |
| Email: |
2853117764@qq.com |
| Products Intro: |
Product Name:Lidocaine-d6 Hydrochloride
CAS:2517378-96-8
Purity:99% HPLC Package:10mg;25mg;50mg;100mg;200mg;500mg
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| | Lidocaine-d6 Hydrochloride Basic information |
| | Lidocaine-d6 Hydrochloride Chemical Properties |
| | Lidocaine-d6 Hydrochloride Usage And Synthesis |
| Uses | Lidocaine-d6 (hydrochloride) is deuterium labeled Lidocaine (hydrochloride). Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor[2]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Cummins TR, et al. Setting up for the block: the mechanism underlying lidocaine's use-dependent inhibition of sodium channels. J Physiol. 2007 Jul 1;582(Pt 1):11. DOI:10.1113/jphysiol.2007.136671
[3] Sui H, et al. Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145. BMC Cancer. 2019 Mar 15;19(1):233. DOI:10.1186/s12885-019-5431-9
[4] Li Z, et al. Evaluation of the antinociceptive effects of lidocaine and bupivacaine on the tail nerves of healthy rats. Basic Clin Pharmacol Toxicol. 2013 Jul;113(1):31-6. DOI:10.1111/bcpt.12061 |
| | Lidocaine-d6 Hydrochloride Preparation Products And Raw materials |
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