| Company Name: |
Shanghai isotope chemical co.,ltd
|
| Tel: |
021-51600108 13062666369 |
| Email: |
sales@isotopechem.com |
| Products Intro: |
Product Name:Prostaglandin J2-d4
CAS:2738376-80-0
Purity:Purity: >=98% Package:100ug Remarks:CA19345
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Prostaglandin J2-d4
CAS:2738376-80-0
Purity:95% Package:25μg;50μg;100μg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:Prostaglandin J2-d4
CAS:2738376-80-0
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Prostaglandin J2-d4
CAS:2738376-80-0
|
|
| | Prostaglandin J2-d4 Basic information |
| Product Name: | Prostaglandin J2-d4 | | Synonyms: | (Z)-3,3,4,4-tetradeuterio-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid | | CAS: | 2738376-80-0 | | MF: | C20H26D4O4 | | MW: | 338.48 | | EINECS: | | | Product Categories: | | | Mol File: | 2738376-80-0.mol |  |
| | Prostaglandin J2-d4 Chemical Properties |
| Boiling point | 521.748±50.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.103±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml |
| | Prostaglandin J2-d4 Usage And Synthesis |
| Description | Prostaglandin J2-d4 is intended for use as an internal standard for the quantification of prostaglandin J2 by GC- or LC-MS. Prostaglandin J2 (PGJ2) is formed from PGD2 by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin.1 PGJ2 inhibits platelet aggregation with an IC50 of about 5-10 nM.2,3 PGJ2 has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines.4 However, this activity has been attributed to further metabolites of PGJ2 and not the parent compound itself. | | Uses | Prostaglandin J2-d4 is the deuterium labeled Prostaglandin J2[1]. | | References | 1. Fitzpatrick, F.A., and Wynalda, M.A. Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro J. Biol. Chem. 258(19),11713-11718(1983).
2. Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues J. Med. Chem. 26(6),790-799(1983).
3. Mahmud, I., Smith, D.L., Whyte, M.A., et al. On the identification and biological properties of prostaglandin J2 Prostaglandins Leukot. Med. 16(2),131-146(1984).
4. Fukushima, M. Prostaglandin J2 - anti-tumor and anti-viral activities and the mechanisms involved Eicosanoids 3(4),189-199(1990). |
| | Prostaglandin J2-d4 Preparation Products And Raw materials |
|