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Shanghai isotope chemical co.,ltd
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Product Name:N-hexanoyl-L-Homoserine lactone-d3
CAS:2705226-73-7
Purity:Purity: >=98% Package:1mg Remarks:CA10007897
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
| Products Intro: |
Product Name:N-hexanoyl-L-Homoserine lactone-d3
CAS:2705226-73-7
Purity:95% Package:500μg;1mg;5mg
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| Company Name: |
Cayman Chemical Company
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| Tel: |
800-364-9897 |
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sales@caymanchem.com |
| Products Intro: |
Product Name:N-hexanoyl-L-Homoserine lactone-d3
CAS:2705226-73-7
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:N-hexanoyl-L-Homoserine lactone-d3
CAS:2705226-73-7
|
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| | N-hexanoyl-L-Homoserine lactone-d3 Basic information |
| | N-hexanoyl-L-Homoserine lactone-d3 Chemical Properties |
| Boiling point | 434.039±34.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.082±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid |
| | N-hexanoyl-L-Homoserine lactone-d3 Usage And Synthesis |
| Description | N-hexanoyl-L-Homoserine lactone-d3 (C6-HSL-d3) contains three deuterium atoms at the C-6 position. It is intended for use as an internal standard for the quantification of C6-HSL by GC- or LC-mass spectrometry. Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. A promising field of study involves controlling bacterial infections by quenching their quorum sensing systems. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. C6-HSL is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and affecting cellular metabolism.1 The diverse applications of this molecule include regulation of virulence in general and in cystic fibrosis, infection prevention, slime and biofilm reduction in commercial agriculture and aquaculture industries, food spoilage prevention, and septicemia in fish.2,3,4,5,6,7,8 | | Uses | N-Hexanoyl-L-Homoserine lactone-d3 (C6-HSL-d3) is deuterium labeled N-Hexanoyl-L-homoserine lactone. N-Hexanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). Diatoms are frequently found in association with Proteobacteria, many members of which employ cell-to-cell communication via AHLs in aquatic habitats[1][2]. | | References | 1. Gould, T.A., Herman, J., Krank, J., et al. Specificity of acyl-homoserine lactone syntheses examined by mass spectrometry J. Bacteriol. 188(2),773-783(2006).
2. Morohoshi, T., Inaba, T., Kato, N., et al. Identification of quorum-sensing signal molecules and the LuxRI homologs in fish pathogen edwardsiella tarda J. Biosci. Bioeng. 98(4),274-281(2004).
3. Ulrich, R.L., Hines, H.B., Parthasarathy, N., et al. Mutational analysis and biochemical characterization of the bukholderia thailandensis DW503 quorum-sensing network J. Bacteriol. 186(13),4350-4360(2004).
4. Wang, L.H., Weng, L.X., Dong, Y.H., et al. Specificity and enzyme kinetics of the quorum-quenching N-acyl homoserine lactone lactonase (AHL-lactonase) J. Biol. Chem. 279(14),13645-13651(2004).
5. Yates, E.A., Philipp, B., Buckley, C., et al. N-acylhomoserine lactones undergo lactonolysis in a pH-temperature-, and acyl chain length-dependent manner during growth of yersinia pseudotuberculosis and pseudomonas aeruginosa Infect. Immun. 70(10),5635-5646(2002).
6. Luo, Z.Q., Su, S., and Farrand, S.K. In situ activation of the quorum-sensing transcription factor TraR by cognate and noncognate acyl-homoserine lactone ligands: Kinetics and consequences J. Bacteriol. 186(19),5665-5672(2003).
7. Christensen, A.B., Riedel, K., Eberl, L., et al. Quorum-sensing-directed protein expression in Serratia proteamaculans B5a Microbiology 149(Pt 2),471-483(2003).
8. Chambers, C.E., Visser, M.B., Schwab, U., et al. Identification of N-acylhomoserine lactones in mucopurulent respiratory secretions from cystic fibrosis patients FEMS Microbiol. Lett. 244(2),297-304(2005). |
| | N-hexanoyl-L-Homoserine lactone-d3 Preparation Products And Raw materials |
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