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| | 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Basic information |
| Product Name: | 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide | | Synonyms: | 2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)-dodecanamid;2,2-DIMETHYL-N-(2,4,6-TRIMETHOXYPHENYL)DODECANAMIDE;CI 976;PD 128042;N-(2,4,6-Trimethoxyphenyl)-2,2-dimethyldodecanamide;CI-976
(PD 128042);Dodecanamide, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-;inhibit,oral,PD128042,PD 128042,CI-976,Diacylglycerol acyltransferase,PD-128042,Acyltransferase,transferase,secretory,LPAT,acyl-CoA:cholesterol acyltransferase,mono- acylglycerol acyltransferase,endocytic membrane trafficking pathway,ACAT,CI976,Diglyceride acyltransferase,Inhibitor | | CAS: | 114289-47-3 | | MF: | C23H39NO4 | | MW: | 393.56 | | EINECS: | | | Product Categories: | Miscellaneous Compounds;Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. | | Mol File: | 114289-47-3.mol |  |
| | 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | solid | | InChI | InChI=1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25) | | InChIKey | WAFNZAURAWBNDZ-UHFFFAOYSA-N | | SMILES | C(NC1=C(OC)C=C(OC)C=C1OC)(=O)C(C)(C)CCCCCCCCCC |
| | 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Usage And Synthesis |
| Description | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) is a sterol O-acyltransferase that catalyzes the formation of fatty acid-cholesterol esters, an important step in lipoprotein assembly and dietary cholesterol absorption. CI-976 is a potent, selective inhibitor of ACAT-1 (IC50 = 73 nM). It is orally bioavailable and decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits given a diet that induces hypercholesterolemia. CI-976 also diminishes atherosclerotic activity in hypercholesterolemic rabbits. | | Uses | CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor:
- to analyze its anti-hepatitis C virus (HCV) activity in Huh7.5.1 cells
- to treat Neuro-2a cells to test its effect on plasma membrane integrated density of α4-SEPβ2 or α6-SEPβ2β3 nicotinic acetylcholine receptors (nAChRs)
- to study its effects on the anti-angiogenic activity of pyripyropenes in human umbilical vein endothelial cells
| | Uses | CI-976 (2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide) is a selective inhibitor of Acyl-coenzyme A: cholesterol Acyltransferase 1 (ACAT-1), a sterol O-acetyltransferase that catalyzes information of fatty acid-cholesterol esters. Orally bioavailable and decreses plasma total cholesterol | | Definition | ChEBI: 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide is an anilide. | | Biological Activity | Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC 50 = 0.073 μ M). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidaemia. Orally active. | | Biochem/physiol Actions | CI-976 (2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide), a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol. | | storage | Store at +4°C |
| | 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Preparation Products And Raw materials |
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