| Company Name: |
TargetMol Chemicals Inc.
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15002134094 |
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Product Name:Folinic acid calcium hydrate
CAS:1097832-14-8
Package:50mg/RMB 19420;25mg/RMB 14900;100mg/RMB 24625
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L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt, hydrate (1:1:1) manufacturers
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| | L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt, hydrate (1:1:1) Basic information |
| Product Name: | L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt, hydrate (1:1:1) | | Synonyms: | L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt, hydrate (1:1:1);Folinic acid calcium hydrate | | CAS: | 1097832-14-8 | | MF: | C20H27CaN7O8 | | MW: | 533.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1097832-14-8.mol | ![L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt, hydrate (1:1:1) Structure](CAS/20211123/GIF/1097832-14-8.gif) |
| | L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt, hydrate (1:1:1) Chemical Properties |
| | L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt, hydrate (1:1:1) Usage And Synthesis |
| Uses | Folinic acid (Leucovorin) calcium hydrate is a biological folic acid and is generally administered along with Methotrexate.html" class="link-product" target="_blank">Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity[1]. | | in vivo | Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) calcium hydrate treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2]. | Animal Model: | 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2] | | Dosage: | 7.0 mg/kg | | Administration: | Intraperitoneal injection; every second day; for 3 weeks | | Result: | Following Mthotrexate (MTX) administration appears to reverse this growth inhibition. |
| | IC 50 | Human Endogenous Metabolite | | References | [1] Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8. DOI:10.1016/s0027-5107(97)00216-9
[2] Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44. PMID:14971796 |
| | L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt, hydrate (1:1:1) Preparation Products And Raw materials |
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