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| | Ro 31-0052 Basic information |
| Product Name: | Ro 31-0052 | | Synonyms: | Ro 31-0052;1-Piperidineethanol, 3-hydroxy-α-[(2-nitro-1H-imidazol-1-yl)methyl]- | | CAS: | 82381-67-7 | | MF: | C11H18N4O4 | | MW: | 270.28502 | | EINECS: | | | Product Categories: | | | Mol File: | 82381-67-7.mol |  |
| | Ro 31-0052 Chemical Properties |
| Boiling point | 547.3±60.0 °C(Predicted) | | density | 1.51±0.1 g/cm3(Predicted) | | pka | 14.06±0.20(Predicted) |
| | Ro 31-0052 Usage And Synthesis |
| Uses | Ro 31-0052 is a basic radiation sensitizer, a 3'-hydroxypiperidine analog of Ro 03-8799, with improved hydrophilicity. This type of designed radiation sensitizer has better pharmacokinetic properties and has the potential to replace clinically used Misonidazole (HY-105061) and Metronidazole (HY-B0318)[1]. | | References | [1] Dennis MF, Stratford MR, Wardman P, Watts ME. Cellular uptake of misonidazole and analogues with acidic or basic functions. Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Jun;47(6):629-43. DOI:10.1080/09553008514550871
[2] Stratford M R L, et al. Pharmacokinetic studies on some novel (2-nitro-1-imidazolyl) propanolamine radiosensitizers[J]. Advanced Topics on Radiosensitizers of Hypoxic Cells, 1982: 165-169. |
| | Ro 31-0052 Preparation Products And Raw materials |
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