| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:AGN 193109 (sodium salt)
CAS:2319838-82-7
Purity:98% Package:500μg;1mg;10mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:AGN 193109 sodium
CAS:2319838-82-7
Package:10mg;50mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:AGN 193109 (sodium salt)
CAS:2319838-82-7
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:AGN 193109 (sodium salt)
CAS:2319838-82-7
|
|
| | AGN 193109 (sodium salt) Basic information |
| | AGN 193109 (sodium salt) Chemical Properties |
| solubility | DMSO: Slightly Soluble
Methanol: Slightly Soluble |
| | AGN 193109 (sodium salt) Usage And Synthesis |
| Uses | AGN 193109 sodium is the sodium salt form of AGN 193109 (HY-U00449). AGN 193109 sodium is the pan antagonist for retinoic acid receptor (RAR), with Kd of 2, 2 and 3 nM, for RARα, RARβ and RARγ, respectively. AGN 193109 sodium reverses TTNPB-induced morphology changes and all-trans retinoic acid (tRA)/9-cis RA/13-cis RA-induced proliferation suppression in ECE16-1 cell. AGN 193109 sodium is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity[1][2]. | | IC 50 | RXR α: 2 nM (Kd); RXR β: 2 nM (Kd); RXR γ: 2 nM (Kd) | | References | [1] Standeven AM, et al. Specific antagonist of retinoid toxicity in mice. Toxicol Appl Pharmacol. 1996 May;138(1):169-75. DOI:10.1006/taap.1996.0110
[2] Agarwal C, et al. AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J Biol Chem. 1996 May 24;271(21):12209-12. DOI:10.1074/jbc.271.21.12209
[3] D M KOCHHAR. The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events.[J]. International Journal of Developmental Biology, 1998, 42 4: 601-608. |
| | AGN 193109 (sodium salt) Preparation Products And Raw materials |
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