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L 692429 manufacturers
- L-692429
-
- $158.00
-
2026-04-28
- CAS:145455-23-8
- Purity: 99.19%
- Supply Ability: 10g
- L-692429
-
- $158.00
-
2026-04-28
- CAS:145455-23-8
- Purity: 99.19%
- Supply Ability: 10g
|
| | L 692429 Basic information |
| Product Name: | L 692429 | | Synonyms: | L 692429;MK 0751;3-amino-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide;L-692,429 , CID121879;L692429,L 692429;Butanamide, 3-amino-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-;L-692429 free base;(R)-N-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-3-amino-3-methylbutanamide | | CAS: | 145455-23-8 | | MF: | C29H31N7O2 | | MW: | 509.611 | | EINECS: | | | Product Categories: | | | Mol File: | 145455-23-8.mol |  |
| | L 692429 Chemical Properties |
| density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 50 mg/mL (98.12 mM) | | pka | 4.14±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | L 692429 Usage And Synthesis |
| Uses | L-692429 (MK-0751) is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 binds to G protein-coupled receptor with a Ki of 63 nM[1][2]. | | in vivo | When tested in anesthetized rats (Wistar rats), L-756867 inhibits L-692429 (100 μg/kg)-stimulated GH secretion in a dose-dependent manner. Complete inhibition is observed at an i.v. dose of 100 μg/kg of L-756867[1]. | | References | [1] Cheng K, et al. Inhibition of L-692,429-stimulated rat growth hormone release by a weak substance P antagonist: L-756,867. J Endocrinol. 1997 Jan;152(1):155-8. DOI:10.1677/joe.0.1520155
[2] Holst B, et al. Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. Mol Endocrinol. 2005 Sep;19(9):2400-11. DOI:10.1210/me.2005-0059
[3] Cunha SR, et al. Ghrelin and growth hormone (GH) secretagogues potentiate GH-releasing hormone (GHRH)-induced cyclic adenosine 3',5'-monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors. Endocrinology. 2002 Dec;143(1 DOI:10.1210/en.2002-220670 |
| | L 692429 Preparation Products And Raw materials |
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