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| | siomycin A Basic information |
| Product Name: | siomycin A | | Synonyms: | Antibiotic 6741-21;Mutabillicin;Mutabilycin;siomycin A;Mutabilycin, SporangioMycin, 6741-21, Mutabillicin;AKFVOKPQHFBYCA-OFENGFFDSA-N;Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexa...;Salomycin A | | CAS: | 12656-09-6 | | MF: | C71H81N19O18S5 | | MW: | 1648.84 | | EINECS: | | | Product Categories: | | | Mol File: | 12656-09-6.mol |  |
| | siomycin A Chemical Properties |
| density | 1.65±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: complete10 mg/ml, clear, colorless to faintly yellow | | form | White solid. | | pka | 10.43±0.46(Predicted) |
| | siomycin A Usage And Synthesis |
| Uses | Siomycin A is an antibiotic that inhibits FoxM1. | | Uses | Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity discovered in 1969. Siomycin is a potent inhibitor of the oncogenic transcription factor, FoxM1. The reduced transcription activity is reflected in the down regulation of protein and mRNA levels of FoxM1 and effects on down stream genes, Cdc25B, survivin and CENPB. In vitro, siomycin inhibits FoxM1-induced cell growth on soft agar and selectively kill transformed but not normal cells. |
| | siomycin A Preparation Products And Raw materials |
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