107889-32-7
中文名称 | 107889-32-7 |
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中文同义词 | 化合物 T15825 |
英文名称 | LY 178002 |
英文同义词 | LY 178002;5-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]thiazolidin-4-one;4-Thiazolidinone, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]- |
CAS号 | 107889-32-7 |
分子式 | C18H25NO2S |
分子量 | 319.46 |
EINECS号 | |
相关类别 | |
Mol文件 | 107889-32-7.mol |
结构式 |
107889-32-7 性质
沸点 | 489.9±45.0 °C(Predicted) |
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密度 | 1.139±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 11.15±0.50(Predicted) |
5-LPO 0.6 μM (IC 50 ) |
PLA2 6.3 μM (IC 50 ) |
FCO 4.2 μM (IC 50 ) |
Cyclooxygenase
|
LY178002 inhibits the generation of LTB4, PLA2 and FCO with IC 50 s of 0.1, 6.3 and 4.2 μM .
LY 178002 (50 mg/kg) inhibits soft tissue swelling in the uninjected paw by 81%, and inhibits bone damage in rats. The minimum effective dose for LY178002 is 10 mg/kg p.o. In the established FCA model LY178002 at 50 mg/kg p.o. inhibits the uninjected paw swelling by 75%.