L-高胱氨酸硫内酯盐酸盐
中文名称 | L-高胱氨酸硫内酯盐酸盐 |
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中文同义词 | L-高胱氨酸硫内酯盐酸盐;L-高半胱氨酸硫内酯盐酸盐;高半胱氨酸硫内酯;L-高半胱氨酸硫代内酯盐酸盐;L-同型半胱氨酸硫内酯 盐酸盐;化合物 T19393;(S)-3-氨基二氢噻吩-2(3H)-酮盐酸盐;L-HCT-HCL |
英文名称 | L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE |
英文同义词 | L-Homocysteine thiolactone hydrochloride,L-2-Amino-4-mercaptobutyric acid 1,4-thiolactone hydrochloride;CAindexname:2(3H)-Thiophenone,3-aminodihydro-,hydr;(S)-3-Aminodihydro-2(3H)-thiophenone hydrochloride;L-HOMOCYSTEINE THIOLACTONE HCL*CRYST;-3-Aminodihydrothiophen-2(3H);H-HOCYS-THIOLACTONE HCL;2(3H)-THIOPHENONE, 3-AMINODIHYDRO-, HYDROCHLORIDE, (3S)-;2(3H)-THIOPHENONE, 3-AMINODIHYDRO-, HYDROCHLORIDE, L- |
CAS号 | 31828-68-9 |
分子式 | C4H8ClNOS |
分子量 | 153.63 |
EINECS号 | 250-824-1 |
相关类别 | |
Mol文件 | 31828-68-9.mol |
结构式 |
L-高胱氨酸硫内酯盐酸盐 性质
熔点 | 185-191 °C |
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储存条件 | Keep in dark place,Inert atmosphere,Room temperature |
溶解度 | 可溶于酸性水溶液(少许)、DMSO(少许)、水(少许) |
形态 | 固体 |
颜色 | 浅米色 |
BRN | 3911455 |
稳定性 | 吸湿性 |
In all cell types, from bacterial to human, homocysteine is metabolized to homocysteine thiolactone by methionyl-tRNA synthetase. Elevated levels of homocysteine are an independent risk factor for cardiovascular disease in humans. Homocysteine can be harmful to human cells because of its metabolic conversion to homocysteine thiolactone, a reactive thioester. This conversion occurs in all human cell types, including endothelial cells. Homocysteine thiolactone induces cell death and features of apoptosis including increased phosphotidylserine exposure on the membrane surface, increased apoptotic cells with hypoploid DNA contents, and internucleosomal DNA fragmentation in HL-60 cells. Homocysteine thiolactone is cytotoxic and capable of promoting cell death, as measured by caspase-3 activation and DNA fragmentation. HcyT strongly activates IL-8 release.
Homocysteine thiolactone is toxic, induces epileptic seizures in rodents, and has been implicated in Alzheimer’s disease. Homocysteine thiolactone induces two types of seizures, the coexistence of convulsive and nonconvulsive epilepsy. The grade of seizures is dose dependent.
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-101404A | L-高胱氨酸硫内酯盐酸盐 L-Homocysteine thiolactone hydrochloride | 31828-68-9 | 10mg | 240元 |
2024/08/19 | HY-101404A | L-高胱氨酸硫内酯盐酸盐 L-Homocysteine thiolactone hydrochloride | 31828-68-9 | 10mM * 1mLin Water | 264元 |