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Chlorpheniramine maleate

Chlorpheniramine maleate Suppliers list
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Products Intro: Product Name:Chlorpheniramine maleate
CAS:113-92-8
Purity:99% Package:1g;1USD
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Products Intro: Product Name:Chlorpheniramine maleate
CAS:113-92-8
Purity:99% Package:1Kg;25kg/ Drum or as customer request
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Products Intro: Product Name:Chlorpheniramine maleate
CAS:113-92-8
Purity:99% Package:25KG;5KG;1KG
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CAS:113-92-8
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Products Intro: Product Name:Chlorphenamine Maleate
CAS:113-92-8
Purity:98% enterprise standard Package:25kg/drum

Chlorpheniramine maleate manufacturers

Chlorpheniramine maleate Basic information
Product Name:Chlorpheniramine maleate
Synonyms:1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethy-laminopropanebimaleate;1-Parachlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate;2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1);Chlorophenamine;Chlorprophenpyridamine maleate;Cloropiril;Histaspan;Pyridine, 2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]-, maleate (1:1) (8CI)
CAS:113-92-8
MF:C20H23ClN2O4
MW:390.86
EINECS:204-037-5
Product Categories:API;TELDRIN;Intermediates & Fine Chemicals;Pharmaceuticals;Antagonists;Histaminergics;Neurotransmitters
Mol File:113-92-8.mol
Chlorpheniramine maleate Structure
Chlorpheniramine maleate Chemical Properties
Melting point 130-135 °C (lit.)
alpha -1~+1°(D/20℃)(c=5,DMF)
density 1.1984 (rough estimate)
refractive index 1.6800 (estimate)
Fp 9℃
storage temp. 2-8°C
solubility Freely soluble in water, soluble in ethanol (96 per cent)
form neat
PH4.0~5.5 (10g/l, 25℃)
Water Solubility 1-5 g/100 mL at 21 ºC
Merck 14,2180
InChIKeyDBAKFASWICGISY-BTJKTKAUSA-N
EPA Substance Registry SystemChlorpheniramine maleate (113-92-8)
Safety Information
Hazard Codes T,F
Risk Statements 25-39/23/24/25-23/24/25-11
Safety Statements 36/37/39-45-36/37-16
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS US6504000
TSCA Yes
HazardClass 6.1(b)
PackingGroup III
HS Code 29333990
ToxicityLD50 orally in mice: 162 mg/kg (Smith)
MSDS Information
ProviderLanguage
Chlorphenamine hydrogen maleate English
SigmaAldrich English
Chlorpheniramine maleate Usage And Synthesis
DescriptionChlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.
Chemical PropertiesWhite Solid
Uses
(±)-Chlorpheniramine maleate salt has been used:
  • as H1 receptor antagonist to determine the receptor function
  • to block the effect of compound 48/80 on plasma IGF-I
  • as a standard for fast sensing and determination by sequential injector coupled with potentiometer

UsesAn antagonist of the histamine H1-receptor
UsesAntihistaminic
Brand nameTrimeton (Schering-Plough); Teldrin (GlaxoSmithKline).
General DescriptionChlorpheniraminemaleate, (±)2-[p-chloro-α-[2-dimethylamino)ethyl]benzyl]pyridine bimaleate (Chlor-Trimeton), is a white crystallinepowder that is soluble in water (1:3.4), in alcohol(1:10), and in chloroform (1:10). It has a pKa of 9.2, and anaqueous solution has a pH between 4 and 5. Chlorination ofpheniramine in the para position of the phenyl ring increasespotency 10-fold with no appreciable change in toxicity.Most of the antihistaminic activity resides with thedextro isomer (see under “Dexchlorpheniramine Maleate” ).The usual dose is 2 to 4 mg 3 or 4 times a day. It has a halflifeof 12 to 15 hours.
General DescriptionOdorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.
Air & Water ReactionsWater soluble.
Reactivity ProfileA halogenated amine, ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Fire HazardFlash point data for Chlorpheniramine maleate are not available; however, Chlorpheniramine maleate is probably combustible.
Biochem/physiol ActionsChlorpheniramine maleate (CPM) can prevent rhinitis and urticaria. It is used to cure several allergic conditions. This antihistamine is used in small-animal veterinary practices.
Safety ProfilePoison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.
Veterinary Drugs and TreatmentsAntihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Chlorpheniramine is one the more commonly used antihistamines in the cat for the treatment of pruritus. It may also be of benefit as a mild sedative in small animals due to its CNS depressant effects.
Dosage forms4 to 6 mg PO q4–6h. Maximum daily dose is 24 mg for adults and children 12 years or older. Found frequently in combination with acetaminophen and pseudoephedrine.
Chlorpheniramine maleate Preparation Products And Raw materials
Raw materials2-Picoline-->Maleic acid-->Bromoacetaldehyde diethyl acetal-->2-(4-Chlorobenzyl)pyridine
Tag:Chlorpheniramine maleate(113-92-8) Related Product Information
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