| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:BHA536
CAS:919992-85-1
Package:50mg/RMB 38300
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| Product Name: | BHA536 | | Synonyms: | BHA536;1H-Pyrrole-2,5-dione, 3-[2-chloro-7-[(dimethylamino)methyl]-1-naphthalenyl]-4-[7-[2-(2-methoxyethoxy)ethoxy]-1H-indol-3-yl]- | | CAS: | 919992-85-1 | | MF: | C30H30ClN3O5 | | MW: | 548.03 | | EINECS: | | | Product Categories: | | | Mol File: | 919992-85-1.mol |  |
| | BHA536 Chemical Properties |
| Boiling point | 758.333±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.326±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 7.029±0.60(predicted) |
| | BHA536 Usage And Synthesis |
| Uses | BHA536 is an orally active selective inhibitor for PKCα/β and NF-kB signaling pathway. BHA536 inhibits the proliferation of CD79-mutated ABC DLBCL cell, arrests cell cycle at G1 phase, and induces apoptosis in TMD8 cell. BHA536 exhibits antitumor efficacy in mice[1]. | | References | [1] Naylor TL, et al., Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas. Cancer Res. 2011 Apr 1;71(7):2643-53. DOI:10.1158/0008-5472.CAN-10-2525 |
| | BHA536 Preparation Products And Raw materials |
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