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| | 3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE Basic information |
| | 3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE Chemical Properties |
| Melting point | 187-190 °C(lit.) | | Boiling point | 50 °C(Press: 40 Torr) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | 2000g/l | | form | Solid | | color | White to Off-White | | PH | 5-6 (500g/l, H2O, 20℃) | | Water Solubility | soluble | | Sensitive | Hygroscopic | | BRN | 3670046 | | InChI | InChI=1S/C5H12ClN.ClH/c1-7(2)5-3-4-6;/h3-5H2,1-2H3;1H | | InChIKey | LJQNMDZRCXJETK-UHFFFAOYSA-N | | SMILES | C(CCCl)N(C)C.Cl | | CAS DataBase Reference | 5407-04-5(CAS DataBase Reference) | | EPA Substance Registry System | 3-Chloro-N,N-dimethyl-1-propanamine hydrochloride (5407-04-5) |
| | 3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White to yellowish crystalline powder | | Uses | 3-(Dimethylamino)propyl chloride hydrochloride (DMPC) is used as intermediate for the syntheses of pharmaceuticals (e.g. amitriptyline, bencyclane, benzydamine, cyclobenzaprine and imipramine). Product Data Sheet | | Uses | Dimethylaminopropyl chloride, hydrochloride is used mainly as a pharmaceutical intermediate for the synthesis of many types of drugs, as an agricultural chemical intermediate, as a photographic chemical intermediate, and as a biochemical reagent for enzyme and other studies. The compound shows mutagenic activity. | | Synthesis | Dithionyl chloride (21 g, 1.2 eq.) was added slowly and dropwise to a stirred solution of 3-dimethylamino-1-propanol (15 g, 1.0 eq.) dissolved in 150 mL of chloroform at 0 °C. Subsequently, the reaction mixture was heated to reflux and maintained for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure to obtain the crude product. The crude product was washed with a mixture of dichloromethane and petroleum ether (1:10, 50 mL, v/v) to give N,N-dimethylaminopropyl chloride hydrochloride (22 g, 98% yield). | | References | [1] Patent: WO2013/97773, 2013, A1. Location in patent: Paragraph 0248
[2] Journal of Polymer Science, Part A: Polymer Chemistry, 2014, vol. 52, # 5, p. 671 - 679 |
| | 3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE Preparation Products And Raw materials |
| Raw materials | Thionyl chloride-->Dimethylamine-->Allyl alcohol-->3-Chloropropylamine hydrochloride-->3-Dimethylamino-1-propanol-->3-Chloro-1-propanol-->Chloroform-->Sulfuryl chloride | | Preparation Products | N,N,N'-TRIMETHYL-1,3-PROPANEDIAMINE-->1-[3-(DIMETHYLAMINO)PROPYL]PIPERAZINE-->3,3'-(2,7-DibroMo-9H-fluorene-9,9-diyl)bis(N,N-diMethylpropan- 1-aMine)-->(E)-Olopatadine Hydrochloride-->N-[3-(2-AMINO-4-CHLOROPHENOXY)PROPYL]-N,N-DIMETHYLAMINE-->2-(3-DIMETHYLAMINO-PROPOXY)-BENZALDEHYDE-->[3-(3-CHLORO-9-OXA-1,2,10-TRIAZA-ANTHRACEN-10-YL)-PROPYL]-DIMETHYL-AMINE-->3-(4-Bromophenoxy)-N,N-dimethylpropylamine |
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