ML-7 HYDROCHLORIDE

ML-7 HYDROCHLORIDE Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:ML-7 HCl
CAS:110448-33-4
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: TianYuan Pharmaceutical CO.,LTD
Tel: +86-755-23284190 13684996853
Email: sales@tianpharm.com
Products Intro: Product Name:ML-7hydrochloride
CAS:110448-33-4
Purity:99% Package:10g 100g 200g 500g 1kg 5kg per barrel
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:1-((5-Iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride
CAS:110448-33-4
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-31175
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
Email: factory@coreychem.com
Products Intro: Product Name:ML-7 HYDROCHLORIDE
CAS:110448-33-4
Purity:99.99% Package:1g;1USD
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:ML-7 hydrochloride
CAS:110448-33-4
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good

ML-7 HYDROCHLORIDE manufacturers

  • ML-7 HYDROCHLORIDE
  • ML-7 HYDROCHLORIDE pictures
  • $0.00 / 1kg
  • 2022-09-08
  • CAS:110448-33-4
  • Min. Order: 1kg
  • Purity: 98%
  • Supply Ability: 1Ton
  • ML-7 HYDROCHLORIDE
  • ML-7 HYDROCHLORIDE pictures
  • $1.00 / 1g
  • 2019-12-24
  • CAS:110448-33-4
  • Min. Order: 1g
  • Purity: 99.99%
  • Supply Ability: 200kg
ML-7 HYDROCHLORIDE Basic information
Product Name:ML-7 HYDROCHLORIDE
Synonyms:1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HCL;1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HYDROCHLORIDE;1-(5-IODONAPHTHALENE-1-SULFONYL)HOMOPIPERAZINE, HCL;1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE;1-(5-iodonaphthalene-1-sulfonyl)-1H-*hexahydro-1,;ML-7, HCl;1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-*HEX AHYDRO-1,4-;1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine, hyd
CAS:110448-33-4
MF:C15H18ClIN2O2S
MW:452.74
EINECS:
Product Categories:All Inhibitors;Inhibitors;Protein Kinase Inhibitors and Activators
Mol File:110448-33-4.mol
ML-7 HYDROCHLORIDE Structure
ML-7 HYDROCHLORIDE Chemical Properties
Melting point 246-249°C dec.
storage temp. -20°C
solubility insoluble in EtOH; ≥15.95 mg/mL in DMSO; ≥8.82 mg/mL in H2O with gentle warming and ultrasonic
form powder
color white
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
ML-7 HYDROCHLORIDE Usage And Synthesis
DescriptionML-7 inhibits smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 μM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. It exhibits a 10-fold more potent inhibition of MLCK than its parent compound ML-9 .
Chemical PropertiesOff-White to Yellow Fine Crystalline Solid
UsesML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.
UsesA potent and selective inhibitor of myosin light chain kinase.
Biochem/physiol ActionsSelective myosin light chain kinase inhibitor.
in vitrorats with myocardial infarction were intravenously infused with rhnrg-1. the cmlck expression and phosphorylated mlc-2v were up-regulated in rat treated with rhnrg-1 significantly. moreover, the restoration of rhnrg-1-induced sarcomeric organization in serum-free cultured neonatal rat cardiomyocytes with rhnrg-1 was inhibited by ml-7 [1].
in vivoadministration of ml-7 from 10 min before ischemia to the first 10 min of reperfusion led to a significant recovery of heart contractility. gel analyses of two-dimensional electrophoresis revealed eight proteins with decreased levels in i/r hearts. six proteins involved in energy metabolism, which were cytochrome b-c1 complex subunit 1, atp synthase beta subunit, cytochrome c oxidase subunit, mitochondrial nadhdehydrogenase, nadhdehydrogenase iron-sulfur protein 8, and succinyl-coa ligase subunit. the other two protein levels decreased in i/r hearts, which were peroxiredoxin-2 and tubulin. in addition, ml-7 treatment increased the level of succinyl-coa ligase, which was a key enzyme involved in the citric acid cycle [2].
storageroom temperature (desiccate)
references[1] gu x,liu x,xu d,li x,yan m,qi y,yan w,wang w,pan j,xu y,xi b,cheng l,jia j,wang k,ge j,zhou m. cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin. cardiovasc res.2010 nov 1;88(2):334-43.
[2] lin hb,cadete vj,sawicka j,wozniak m,sawicki g. effect of the myosin light chain kinase inhibitor ml-7 on the proteome of hearts subjected to ischemia-reperfusion injury. j proteomics.2012 sep 18;75(17):5386-95.
ML-7 HYDROCHLORIDE Preparation Products And Raw materials
Tag:ML-7 HYDROCHLORIDE(110448-33-4) Related Product Information
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