| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:ProgluMetacin Dioxalate
CAS:57132-53-3
Package:100Mg,10Mg
|
| Company Name: |
Capot Chemical Co., Ltd
|
| Tel: |
+86 (0) 571 85 58 67 18 |
| Email: |
sales@capotchem.com |
| Products Intro: |
Product Name:Proglumetacin
CAS:57132-53-3
Purity:98% Package:1G;5G;10G;25G Remarks:18227
|
| Company Name: |
Pure Chemistry Scientific Inc.
|
| Tel: |
001-857-928-2050 or 1-888-588-9418 |
| Email: |
sales@chemreagents.com |
| Products Intro: |
Product Name:ProgluMetacin
CAS:57132-53-3
Purity:99% Package:100Mg
|
|
| | PROGLUMETACIN MALEATE Basic information |
| Product Name: | PROGLUMETACIN MALEATE | | Synonyms: | PROGLUMETACIN;PROGLUMETACIN MALEATE;Proglumetacine;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester (9CI);1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester, (+-)-;1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester | | CAS: | 57132-53-3 | | MF: | C46H58ClN5O8 | | MW: | 844.43 | | EINECS: | | | Product Categories: | | | Mol File: | 57132-53-3.mol |  |
| | PROGLUMETACIN MALEATE Chemical Properties |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) | | form | Solid | | color | White to Pale Yellow |
| | PROGLUMETACIN MALEATE Usage And Synthesis |
| Uses | Proglumetacin Dioxalate is a new non-steroidal anti-inflammatory drug. | | Definition | ChEBI: A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N2-benzoyl-N,N-dipropy
-alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretor
effects that helps prevent injury to the stomach lining. | | Synthesis | The reaction of N-benzoyl-N_x0002_,
N_x0002_-di-n-propyl-dl-isoglutamin (proglumide) with 1-(3-chloropropyl)-4-(2-hydroxyethyl)-piperazine
obtained from 1-(2-hydroxyethyl)piperazine
and 1-bromo-3-chloropropane by
means of sodium methanolate in DMSO at
105?C gives N--N_x0002_-(2-hydroxyethyl)
piperazine, which is then condensated
with Indomethacin (1-(p-chlorobenzoyl)-
5-methoxy-2-methylindole-3-acetic acid)
by means of dicyclohexylcabodiimide and
NaHCO3 in ethyl acetate .
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| | PROGLUMETACIN MALEATE Preparation Products And Raw materials |
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