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CL-421

CL-421 Basic information
Product Name:CL-421
Synonyms:CL-421;1-[1-(2-Thienyl)cyclohexyl]piperidine Hydrochloride;GK 0;Thienylcyclidine;Thienylphencyclidine;1-(1-thiophen-2-ylcyclohexyl)piperidine:hydrochloride
CAS:1867-65-8
MF:C15H24ClNS
MW:285.87576
EINECS:
Product Categories:Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:1867-65-8.mol
CL-421 Structure
CL-421 Chemical Properties
Melting point 233-236 °C
solubility DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml; Ethanol: 2 mg/ml; Methanol: 1 mg/ml
form A crystalline solid
Safety Information
MSDS Information
CL-421 Usage And Synthesis
DescriptionTenocyclidine (TCP), known more formally as N-[1-(2-thienyl)cyclohexyl] piperidine, is an analog of phencyclidine (PCP) in which the phenyl substituent is replaced with a thiophene group. TCP is a potent antagonist of the NMDA receptor-gated ion channel (Kd = 9 nM). TCP blocks NMDA-activated excitatory postsynaptic potential in brain more potently than PCP. PCP and many analogs, including TCP, block the uptake and enhance the release of dopamine both in vitro and in vivo. TCP is regulated as a Schedule I compound in the United States. This product is intended for forensic and research applications.
UsesAn analog of the hallucinogen Phencyclidine (P295500).
CL-421 Preparation Products And Raw materials
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