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| | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester Basic information | | Uses |
| Product Name: | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester | | Synonyms: | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester;Ethyl 4-Methyl-3-((4-(pyridin-3-yl)pyriMidin-2-yl)aMino)benzoate;Benzoic acid, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-, ethyl ester;Ethyl 4-methyl-3-((4-(pyridin-3-yl);Nilotinib intermediate 2;Ethyl 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoate | | CAS: | 641569-97-3 | | MF: | C19H18N4O2 | | MW: | 334.37 | | EINECS: | | | Product Categories: | | | Mol File: | 641569-97-3.mol | ![4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester Structure](CAS2/GIF/641569-97-3.gif) |
| | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester Chemical Properties |
| density | 1.233 | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester Usage And Synthesis |
| Uses | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic Acid Ethyl Ester-D6 is an intermediate in the synthesis of Nilotinib-d6 (N465303), which is the labeled analogue of Nilotinib, which might be useful in treatment of chronic myelogenous leukemia. | | Description | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester is a pharmaceutical intermediate compound used in the preparation of nilotinib, a transactivation inhibitor targeting BCR-ABL, c-kit, and PDGF, which is used in the treatment of a variety of leukaemia, including chronic granulocytic leukaemia (CML). Chronic granulocytic leukaemia (CML) is caused by the BCR-ABL oncogene. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. | | Uses | Ethyl 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoate is used in preparation of the Smo inhibitor and synthesis and their application. |
| | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester Preparation Products And Raw materials |
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