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Dimethyl phosphite

Dimethyl phosphite Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
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Products Intro: Product Name:Dimethyl phosphite
CAS:868-85-9
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: CAS:868-85-9
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
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Products Intro: Product Name:Dimethyl phosphonate
CAS:868-85-9
Company Name: Xiamen AmoyChem Co., Ltd
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Products Intro: Product Name:Dimethyl phosphonate
CAS:868-85-9
Company Name: Changzhou Ditong Chemical Co.,Ltd
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Products Intro: Product Name:Dimethyl phosphite
CAS:868-85-9
Package:10kg 25kg 200 kilograms per barrel
Dimethyl phosphite Basic information
Product Name:Dimethyl phosphite
Synonyms:Olaparib Impurity 22;dimethylesterkyselinifosforite(czech);dimethylesterkyselinyfosforite;Dimethylfosfit;Dimethylfosfonat;dimethylhydrogenphosphonate;Dimethylphosphit;dimethylphosphorousacid
CAS:868-85-9
MF:C2H7O3P
MW:110.05
EINECS:212-783-8
Product Categories:PETRO CATALYST;-;Pharmaceutical Intermediates;Organic Building Blocks;Organic Phosphates/Phosphites;Phosphorus Compounds;Building Blocks;Chemical Synthesis;Organic Building Blocks;Organic Phosphates/Phosphites;Phosphorus Compounds
Mol File:868-85-9.mol
Dimethyl phosphite Structure
Dimethyl phosphite Chemical Properties
Boiling point 170-171 °C(lit.)
density 1.2 g/mL at 25 °C(lit.)
refractive index n20/D 1.402(lit.)
Fp 71 °C
Water Solubility Soluble in water.
Sensitive Moisture Sensitive
BRN 1697490
Stability:Stable. Moisture sensitive. Incompatible with water, strong oxidizing agents, acid chlorides, strong bases.
CAS DataBase Reference868-85-9(CAS DataBase Reference)
NIST Chemistry ReferencePhosphonic acid, dimethyl ester(868-85-9)
EPA Substance Registry SystemPhosphonic acid, dimethyl ester(868-85-9)
Safety Information
Hazard Codes Xn
Risk Statements 21-36-10-68-52/53-43-40
Safety Statements 26-36/37-61
RIDADR UN 3278 6.1/PG 3
WGK Germany 1
RTECS SZ7710000
TSCA Yes
HazardClass 3.2
PackingGroup III
HS Code 29209013
Hazardous Substances Data868-85-9(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Dimethyl phosphite English
SigmaAldrich English
ALFA English
Dimethyl phosphite Usage And Synthesis
Chemical Propertiescolourless liquid
Uses
  1. Dimethyl Phosphite(DMP)is used as a reagent in the synthesis of 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors.
  2. It is also used as a reagent in the synthesis of estafiatin phosphonate derivatives which exhibit antibacterial and antifungal activity.
  3. Dimethyl Phosphite is a degradation product of the pesticides trichlorphon and malathion and may be released into the envionment following their application. It is a contaminant (approxiately 2%) in the chemical intermediate triethyl phosphite, which hydrolyses readily to dimethyl hydrogen phosphite in the presence of moist air or water.
  4. Dimethyl Phosphite is used as a flame retardant on Nylon 6 fibres  and, in combination with guanidine and formaldehyde, to impart flame and crease resistance to cotton textiles. The compound is also used to increase fire resistance to cellulosic textiles, acrolein-grafted polyamide fibres and y-irdiated polyethylene.
  5. lt is used as a lubricant additive, as a chemical intermediate in the production of organophosphorous pesticides and as an adhesive.
  6. Dimethyl Phosphite has also been used as a stabilizer in oil and plaster and, in combination with pyroctechol, as a corrosion inhibitor on steel.
ApplicationDMP is a basic chemical which is used industrially as an intermediate. Because of its reactivity
DMP participates in a large number of chemical reactions:
  • Addition to oxo compounds
  • Addition to oxo compounds with subsequent condensation e.g. with amines
  • Oxidation with oxygen or chlorine
  • Addition to alkenes
Due to these properties DMP is used as an intermediate for the manufacturing of
  • water treatment chemicals e.g. corrosion inhibitors for cooling-water circuits (about 50 %)
  • pesticides and pharmaceuticals (about 20 %)
  • flame retardants and other specialities (about 15 %)
  • textile finishing products (about 15 %)
Health HazardDimethyl Phosphite (DMP) is rapidly absorbed via the oral and dermal routes. The main metabolic pathway in rodents is demethylation to monomethyl hydrogen phosphite (MMP) and further oxidation to CO2. DMP was mainly eliminated via urine and expired air. Over the studied dose range between 10 and 200 mg/kg bw and 5 x 200 mg/kg bw, respectively, only little evidence of bioaccumulation or saturation of absorption and elimination was observed. The only difference in studied toxicokinetics between rats and mice was the more rapid metabolism and elimination in mice.
An inhalation LC50 value is not available, but an exposure of 7100 mg/m³ (concentration estimated based on air flow and net loss of material) over 6 hours was not lethal for rats, mice and guinea pigs. Clinical signs were observed in mice only, and included occasionally laboured respiration after approximately 2 hours of exposure and ptosis after 5 hours. The acute dermal LD50 was 681 mg/kg bw (rabbits). Signs of intoxication were depression, ptosis, labored respiration, ataxia and placidity. The acute oral LD50 values were: 3283 mg/kg bw for male rats, 3040 mg/kg bw for female rats, 2815 mg/kg bw for male mice, and between 2150 and 3160 mg/kg bw for female mice. Clinical signs were inactivity, weakness, prostration and shallow breathing at doses near to or exceeding the LD50 values. White opaque eyes were seen in male mice.
Dimethyl Phosphite is irritating to the skin and eyes of rabbits. After prolonged or repeated exposures moderate to severe irritation of skin and mucosa was observed in rats. No sensitisation studies are available.
Proposed metabolic pathways of DMP in rats and mice
Proposed metabolic pathways of DMP in rats and mice (Nomeir and Matthews, 1997).
Safety ProfileSuspected carcinogen with experimental carcinogenic data. Moderately toxic by ingestion and skin contact. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of POx
Tag:Dimethyl phosphite(868-85-9) Related Product Information
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