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| Paquinimod Basic information |
Product Name: | Paquinimod | Synonyms: | Paquinimod;ABR?215757;N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide;ABR 25757;ABR 25757;ABR-25757;ABR25757;PAQUINIMOD;248282-01-1;ABR25757;ABR-25757;ABR?215757; ABR 215757; ABR215757; PAQUINIMOD. | CAS: | 248282-01-1 | MF: | C21H22N2O3 | MW: | 350.41 | EINECS: | | Product Categories: | | Mol File: | 248282-01-1.mol | |
| Paquinimod Chemical Properties |
Boiling point | 487.3±45.0 °C(Predicted) | density | 1.267±0.06 g/cm3(Predicted) | storage temp. | 2-8°C | solubility | DMSO:15.0(Max Conc. mg/mL);42.8(Max Conc. mM) | form | A solid | pka | 4.50±1.00(Predicted) | color | White to off-white |
| Paquinimod Usage And Synthesis |
Uses | Paquinimod is a S100A9 inhibitor preventing S100A9 binding to TLR-4. Paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Paquinimod treatment of collagenase-induced OA (CIOA) resulted in significantly reduced synovial thickening (57%), osteophyte size at the medial femur (66%) and cruciate ligaments (67%) and cartilage damage at the medial tibia (47%) and femur (75%; n=7, untreated n=6). Paquinimod reduces leukocyte recruitment during sterile inflammation. Paquinimod also reduced priming of proinflammatory effector CD4(+) T cells. |
| Paquinimod Preparation Products And Raw materials |
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