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KU57788(NU7441)

KU57788(NU7441) Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:NU7441
CAS:503468-95-9
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:KU57788(NU7441)
CAS:503468-95-9
Purity:99% Package:1kg;2USD
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:KU57788
CAS:503468-95-9
Purity:98% HPLC LCMS Package:10G;20G
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Email: linda@hubeijusheng.com
Products Intro: Product Name:KU57788(NU7441)
CAS:503468-95-9
Purity:0.99 Package:5KG;1KG
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-61398051 +8613650506873
Email: sales@chemdad.com
Products Intro: Product Name:KU57788(NU7441)
CAS:503468-95-9
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg

KU57788(NU7441) manufacturers

  • KU57788(NU7441)
  • KU57788(NU7441) pictures
  • $2.00 / 1kg
  • 2019-07-06
  • CAS:503468-95-9
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
KU57788(NU7441) Basic information
Product Name:KU57788(NU7441)
Synonyms:KU57788(NU7441);NU 7441;8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one;8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one;NU7441 (KU-57788);KU 57788; NU-7441;KU 57788;NU-7441 (KU-57788);4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-
CAS:503468-95-9
MF:C25H19NO3S
MW:413.49
EINECS:
Product Categories:Inhibitors;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:503468-95-9.mol
KU57788(NU7441) Structure
KU57788(NU7441) Chemical Properties
Melting point 220-221 °C
Boiling point 646.9±55.0 °C(Predicted)
density 1.376±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble in DMSO (up to 10 mg/ml with warming).
form solid
pka0.51±0.20(Predicted)
color Off-white to beige
Stability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
MSDS Information
KU57788(NU7441) Usage And Synthesis
DescriptionDNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and topoisomerase II poisons, modulating DNA-PK is one strategy to defer cancer cell resistance to radiation or chemotherapeutic treatments. NU 7441 is a selective DNA-PK inhibitor with an IC50 value of 14 nM. It inhibits other members of the PI3K-related kinase family, including mTOR, PI3K, ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) with IC50 values of 1.7, 5, >100, and >100 μM, respectively. NU 7441 has been shown to increase the cytotoxicity of ionizing radiation and etoposide in human colon cancer cell lines in vitro and to potentiate the effects of etoposide in mice bearing human colon cancer xenograft tumors in vivo.
UsesA potent novel DNA-dependent protein kinase inhibitor models of human cancer. Antitumor agent.
UsesA potent and selective DNA-PK inhibitor with an IC50 of 14 nM.
DefinitionChEBI: 8-(4-dibenzothiophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of dibenzothiophenes.
storageStore at +4°C
References1) Leahy?et al.?(2004),?Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries; Bioorg. Med. Chem. Lett.,?14?6083 2) Hardcastle?et al.?(2005),?Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach: J. Med. Chem.,?48?7829 3) Zhao?et al.?(2006),?Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441: Cancer Res.?66?5354 4) Ciszewski?et al.?(2014),?DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin: Breast Cancer Res. Treat.,?143?83 5) Yang?et al.?(2016),?NU7441 Enhances the Radiosensitivity of Liver Cancer Cells: Cell Physiol. Biochem.,?38?1897 6) Geng?et al.?(2019),?DNA-PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy: Oncol. Rep.,?42?561
KU57788(NU7441) Preparation Products And Raw materials
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