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| | Mesaconine Basic information |
| Product Name: | Mesaconine | | Synonyms: | Mesaconine;(1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-1,6,16-Trimethoxy-4-(methoxymethyl)-20-methyl-aconitane-3,8,13,14,15-pentol;product/155130;Aconitane-3,8,13,14,15-pentol, 1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-, (1α,3α,6α,14α,15α,16β)-;(1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-1,6,16-Trimethoxy-4-(methoxymethyl)-20-methyl-aconitane;Inhibitor,inhibit,Mesaconine | | CAS: | 6792-09-2 | | MF: | C24H39NO9 | | MW: | 485.57 | | EINECS: | | | Product Categories: | Alkaloids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 6792-09-2.mol |  |
| | Mesaconine Chemical Properties |
| Boiling point | 617.1±55.0 °C(Predicted) | | density | 1.44±0.1 g/cm3(Predicted) | | solubility | Aqueous Acid (Slightly), Chloroform (Slightly), Methanol (Slightly) | | pka | 12.22±0.70(Predicted) | | form | Solid | | color | White | | Stability: | Moisture Sensitive |
| | Mesaconine Usage And Synthesis |
| Uses | New use of neoaconitrile in the preparation of medicaments for preventing and/or treating myocardial fibrosis and chronic heart failure caused by myocardial fibrosis | | Biological Activity | Mesaconinean, the active ingredient extracted from Aconitum carmichaelii Debx., has cardiovascular effects. | | Pharmacology | 1) Inhibit or reverse myocardial tissue fibrosis; 2) Improve abnormal cardiac remodeling; 3) Improve cardiac dysfunction; 4) Improve the survival rate of mice with chronic heart failure caused by myocardial fibrosis; 5) Fight against myocardial tissue inflammation; 6 ) Inhibition of cardiomyocyte apoptosis; 7) Myocardial enzyme activity in dead mice, and its mechanism of action is related to inhibiting myocardial tissue inflammation and fibrosis caused by adriamycin and resisting cardiomyocyte apoptosis. |
| | Mesaconine Preparation Products And Raw materials |
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