ChemicalBook > Product Catalog >Analytical Chemistry >Standard >Analytical Standards >2,5-DiMethyl Celecoxib

2,5-DiMethyl Celecoxib

2,5-DiMethyl Celecoxib Suppliers list
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:2,5-Dimethyl Celecoxib
CAS:457639-26-8
Purity:98% HPLC LCMS Package:10G;20G
Company Name: Standardpharm Co. Ltd.
Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Products Intro: Product Name:Celecoxib Impurity 42
CAS:457639-26-8
Purity:0.99 Package:10mg;25mg;50mg;100mg
Company Name: Hangzhou Huarong Pharm Co., Ltd.
Tel: 571-86758373 +8613588754946
Email: sales@huarongpharm.com
Products Intro: Product Name:4-(5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl) benzenesulfonamide
CAS:457639-26-8
Purity:0.99 Package:10MG,50MG,100MG,1G
Company Name: Alfa Chemistry
Tel: +1-5166625404
Email: Info@alfa-chemistry.com
Products Intro: Product Name:2,5-Dimethyl-celecoxib
CAS:457639-26-8
Purity:98%+
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:2,5-dimethyl Celecoxib
CAS:457639-26-8
Package:1 mg;10 mg;100 mg;200 mg;25 mg;5 mg;50 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
2,5-DiMethyl Celecoxib Basic information
Product Name:2,5-DiMethyl Celecoxib
Synonyms:4-[5-(2,5-DiMethylphenyl)-3-(trifluoroMethyl)-1H-pyrazol-1-yl]benzenesulfonaMide;2,5-DiMethyl-celecoxib DMC;2,5-Dimethylcelecoxib 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide;2,5-DiMethyl Celecoxib;4-[5-(2,5-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide;Celecoxib-13;Celecoxib Impurity 42;Celecoxib Impurity K
CAS:457639-26-8
MF:C18H16F3N3O2S
MW:395.4
EINECS:
Product Categories:Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:457639-26-8.mol
2,5-DiMethyl Celecoxib Structure
2,5-DiMethyl Celecoxib Chemical Properties
Melting point >138°C (dec.)
Boiling point 516.7±60.0 °C(Predicted)
density 1.40±0.1 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: soluble20mg/mL, clear
pka9.67±0.10(Predicted)
form powder
color white to beige
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
MSDS Information
2,5-DiMethyl Celecoxib Usage And Synthesis
Uses2,5-Dimethyl-celecoxib has been used
  • To block the synthesis of prostaglandin E2 and to study effect of transforming growth factor-2 signaling towards cyclooxygenase-2 expression.
  • In an in vitro study to analyze its pro-oxidative capacities in metastatic melanoma/ breast cancer cells.
  • To study its interaction between silymarin on chemically induced osteoarthritis in rats.

UsesA non-cyclooxygenase-2 inhibitor analog of Celecoxib (C251000). The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib.
Biochem/physiol ActionsCelecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.
storageRoom temperature
2,5-DiMethyl Celecoxib Preparation Products And Raw materials
Tag:2,5-DiMethyl Celecoxib(457639-26-8) Related Product Information