- Nortadalafil
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- $0.00 / 1ASSAYS
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2021-10-29
- CAS:171596-36-4
- Min. Order: 100ASSAYS
- Purity: 99.99
- Supply Ability: 10000
- Nortadalafil
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- $7.00 / 1KG
-
2020-01-03
- CAS: 171596-36-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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| | Nortadalafil Basic information |
| Product Name: | Nortadalafil | | Synonyms: | (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;Nortadalafil;Tadalafil IMpurity:IMpurity C;Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-, (6R,12aR)-;(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, N-DesMethyl Tadalafil;Tadalafil IMpurity J;Tadanafil N-desmethyl impurity;DeMethyltadalafil | | CAS: | 171596-36-4 | | MF: | C21H17N3O4 | | MW: | 375.38 | | EINECS: | | | Product Categories: | Aromatics;Drug Analogues;Heterocycles;Indole Derivatives;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 171596-36-4.mol |  |
| | Nortadalafil Chemical Properties |
| Melting point | 285-290℃ (methanol ) | | Boiling point | 718.6±60.0 °C(Predicted) | | density | 1.55±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | form | Solid | | pka | 13.53±0.40(Predicted) | | color | White to Pale Yellow |
| | Nortadalafil Usage And Synthesis |
| Uses | A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil (T004500). A potential antiplasmodial drug. | | Biological Activity | the cgmp-specific pde5 is the major pde isozyme in the corpus cavernosum, and controls penile erection. the pde5 inhibitors used in the clinic amplify the no-ccmp pathway and enhance the normal process leading to penile erection.nortadalafil is demethyl tadalafil, which is a pde5 inhibitor currently marketed in pill form for treating erectile dysfunction under the name cialis and for the treatment of pulmonary arterial hypertension under the name adcirca. | | in vitro | tadalafil has been identified as a highly potent pde5 inhibitor (ic50 = 5 nm) with high selectivity for pde5 vs pde1-4 and pde6. it displays 85-fold greater selectivity vs pde6 than sildenafil [1]. | | in vivo | tadalafil showed profound and long-lasting blood pressure lowering activity (30 mmhg/>7 h) in the spontaneously hypertensive rat model after oral administration (5 mg/kg) [1]. | | target | PDE5 | | IC 50 | n/a for nortadalafil; 5 nm for tadalafil | | references | [1] daugan a, grondin p, ruault c, le monnier de gouville ac, coste h, linget jm, kirilovsky j, hyafil f, labaudinière r. the discovery of tadalafil: a novel and highly selective pde5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. j med chem. 2003;46(21):4533-42.
[2] porst h, hell-momeni k, büttner h. chronic pde-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. expert opin pharmacother. 2012 jul;13(10):1481-94. doi: 10.1517/14656566.2012.693162. |
| | Nortadalafil Preparation Products And Raw materials |
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