| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:rac-cis 3-Methyl-N-phenylaMino-4-piperidinaMine N-Trifluroacetate
CAS:958025-66-6
Package:50Mg,5Mg
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| Company Name: |
Hangzhou Sage Chemical Co., Ltd.
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| Tel: |
+86057186818502 13588463833 |
| Email: |
info@sagechem.com |
| Products Intro: |
Product Name:(S)-1-(4-(2-(6-aMino-8-(6-broMobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)ethyl)piperidin-1-yl)-2-hydroxypropan-1-one
CAS:958025-66-6
Purity:98% Package:1g;5g;100g;Bulk
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| Company Name: |
NCE Biomedical Co.,Ltd.
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| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
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| Products Intro: |
Product Name:MPC-3100
CAS:958025-66-6
Purity:99% HPLC Package:50Mg,100Mg,500Mg,1g,5g,10g,50g,100g,500g,1kg Remarks:XYA0681
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| Company Name: |
shanghai cooperpharm co.,LTD .
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| Tel: |
+86-021-58975553 |
| Email: |
sales@cooperpharm.com |
| Products Intro: |
Product Name:(S)-1-(4-(2-(6-aMino-8-((6-broMobenzo[d][1,3]dioxol-5-yl)thio)-9H-purin-9-yl)ethyl)piperidin-1-yl)-2-hydroxypropan-1-one
CAS:958025-66-6
Purity:99%HPLC Package:5OMg,,250Mg,1g,10g,250g,1kg,5kg
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| | MPC3100 Basic information |
| Product Name: | MPC3100 | | Synonyms: | MPC3100;(2S)-1-[4-[2-[6-Amino-8-[(6-bromo-1,3-benzodioxol-5-yl)thio]-9H-purin-9-yl]ethyl]-1-piperidinyl]-2-hydroxy-1-propanone;CS-215;(2S)-1-[4-[2-[6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]purin-9-yl]ethyl]piperidin-1-yl]-2-hydroxypropan-1-one;1-Propanone, 1-[4-[2-[6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)thio]-9H-purin-9-yl]ethyl]-1-piperidinyl]-2-hydroxy-, (2S)- | | CAS: | 958025-66-6 | | MF: | C22H25BrN6O4S | | MW: | 549.44 | | EINECS: | 200-258-5 | | Product Categories: | | | Mol File: | 958025-66-6.mol |  |
| | MPC3100 Chemical Properties |
| Boiling point | 772.4±70.0 °C(Predicted) | | density | 1.77±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Powder | | pka | 13.95±0.20(Predicted) |
| | MPC3100 Usage And Synthesis |
| Uses | MPC-3100 is a recently discovered fully synthetic purine-based Hsp90 Inhibitor exhibiting anticancer properties | | Biological Activity | mpc-3100 is a purine-based inhibitor of hsp90 with ic50 value of 60nm [1].mpc-3100 targets the n-terminal atp-binding site of hsp90 and blocks the activity of atpase. in the her2-luciferase degradation assay, mpc-3100 reduces this client protein of hsp90 with ic50 value of 60nm. in hct-116 cell lines, mpc-3100 inhibits cell proliferation with ic50 value of 540nm. besides that, mpc-3100 shows a broad spectrum anti-proliferative activity against various cancer cell lines, such as nci-n87 and du-145. mpc-3100 also inhibits tumor growth in the nci-n87 gastric cancer xenograft mode. moreover, pk studies show that mpc-3100 displays a superior oral pk profile, good overall exposure and a reasonable hepatic clearance rate. phase i clinical studies demonstrate mpc-3100 is safe and tolerated when administered at doses below 600 mg per day [1]. | | references | [1] kim sh, bajji a, tangallapally r, markovitz b, trovato r, shenderovich m, baichwal v, bartel p, cimbora d, mckinnon r, robinson r, papac d, wettstein d, carlson r, yager km. discovery of (2s)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9h-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (mpc-3100), a purine-based hsp90 inhibitor. j med chem. 2012 sep 13;55(17):7480-501. |
| | MPC3100 Preparation Products And Raw materials |
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