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| | Bavisant (dihydrochloride) Basic information |
| | Bavisant (dihydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder |
| | Bavisant (dihydrochloride) Usage And Synthesis |
| Uses | Bavisant (JNJ-31001074) dihydrochloride is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant dihydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3]. | | in vivo | Bavisant dihydrochloride increases acetylcholine levels in rat frontal cortex[4]. | | IC 50 | H3 receptor | | References | [1] Hudkins RL, et al. Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist. J Med Chem. 2011 Jul 14;54(13):4781-92. DOI:10.1021/jm200401v
[2] Weisler RH, et al. Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34. DOI:10.2165/11631990-000000000-00000
[3] Ghoshal A, et al. Identification of novel β-lactams and pyrrolidinone derivatives as selective Histamine-3 receptor (H3R) modulators as possible anti-obesity agents. Eur J Med Chem. 2018 May 25;152:148-159. DOI:10.1016/j.ejmech.2018.04.020
[4] Ghamari N, et al. Histamine H3 receptor antagonists/inverse agonists: Where do they go? Pharmacol Ther. 2019 Aug;200:69-84. DOI:10.1016/j.pharmthera.2019.04.007 |
| | Bavisant (dihydrochloride) Preparation Products And Raw materials |
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