益智二肽
| 中文名称 | 益智二肽 |
|---|---|
| 中文同义词 | 益智二肽;化合物DIHEXA;N-((S)-1-(((2S,3S)-1-((6-氨基-6-氧代己基)氨基)-3-甲基-1-氧代戊烷-2-基)氨基)-3-(4-羟基苯基)-1-氧代丙烷-2-基)己酰胺 |
| 英文名称 | Dihexa |
| 英文同义词 | Dihexa;N-hexanoic-Try-Ile-(6)-amino hexanoic amide;Dihexa (PNB-0408);N-(1-OXOHEXYL)-L-TYROSYL-N-(6-AMINO-6-OXOHEXYL)-L-ISOLEUCINAMIDE;L-Isoleucinamide, N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;TIANFUCHEM--1401708-83-5---Dihexa;Hexanoyl-Tyr-Ile-Ahx-NH2;PNB-0408 |
| CAS号 | 1401708-83-5 |
| 分子式 | C27H44N4O5 |
| 分子量 | 504.66 |
| EINECS号 | 227-005-2 |
| 相关类别 | 多肽中间体;武汉贝尔卡主打 |
| Mol文件 | 1401708-83-5.mol |
| 结构式 |  |
益智二肽 性质
| 熔点 | >209°C (dec.) |
|---|---|
| 沸点 | 866.2±65.0 °C(Predicted) |
| 密度 | 1.111±0.06 g/cm3(Predicted) |
| 储存条件 | Hygroscopic, Refrigerator, under inert atmosphere |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.83±0.15(Predicted) |
| 颜色 | 白色至类白色 |
| 序列 | Hexanoyl-Tyr-Ile-Ahx-NH2 |
| InChIKey | ADWKPLXLPNPJTR-JTJYXVOQSA-N |
| SMILES | C(N)(=O)[C@H]([C@@H](C)CC)N(C(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)CCCCC)CCCCCC(N)=O |
Kd: 65 pM (HGF)
Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself. Dihexa effectively inhibits HGF dimerization at 1 μM. While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met.
Dihexa has a long circulating half-life. Dihexa exhibits procognitive activity. Dihexa reverses scopolamine-dependent spatial learning deficits. It improves spatial learning in aged rats. Dihexa induces spinogenesis in cultured hippocampal neurons.
纯度(HPLC) ≥98.0%
醋酸根含量5.0%～12.0%
水分含量≤8.0%
肽含量≥80.0%
氨基酸组成分析≤±10%