| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Email: |
eric_feng1954@126.com |
| Products Intro: |
Product Name:Aurora-coMpound 1
CAS:1234481-08-3
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:XMD-12
CAS:1234481-08-3
Package:100mg/RMB 17500;50mg/RMB 13800;25mg/RMB 10600
|
Aurora-coMpound 1 manufacturers
- XMD-12
-
- $2500.00 / 100mg
-
2025-08-21
- CAS:1234481-08-3
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | Aurora-coMpound 1 Basic information |
| Product Name: | Aurora-coMpound 1 | | Synonyms: | Aurora-coMpound 1;2-[4-(4-hydroxypiperidin-1-yl)anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one;6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dimethyl-;XMD-12 | | CAS: | 1234481-08-3 | | MF: | C24H26N6O2 | | MW: | 430.5 | | EINECS: | | | Product Categories: | | | Mol File: | 1234481-08-3.mol |  |
| | Aurora-coMpound 1 Chemical Properties |
| Boiling point | 704.8±70.0 °C(Predicted) | | density | 1.328±0.06 g/cm3(Predicted) | | pka | 14.81±0.20(Predicted) |
| | Aurora-coMpound 1 Usage And Synthesis |
| Description | XMD-12, also known as DUN57447, Aurora inhibitor (compound 1) or Aurora-IN-1, is an Auroro inhibitor, which targets Aurora A/B/C. (5.6/18.4/24.6 nM). | | Uses | Aurora kinase-IN-5 (compound 1) is an Aurora kinase (Aurora Kinase) inhibitor with anti-tumor activity that promotes paclitaxel (HY-B0015) induced cell death. Aurora kinase-IN-5 exhibits high selectivity and potency against Aurora A, B, and C kinases, with IC50 values of 5.6, 18.4, and 24.6 nM, respectively[1]. | | IC 50 | Aurora A: 5.6 nM (IC50); Aurora B: 18.4 nM (IC50); Aurora C: 24.6 nM (IC50) | | References | [1] Nicholas Kwiatkowski, et al. Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen. ACS Chem Biol. 2012 Jan 20;7(1):185-96. DOI:10.1021/cb200305u |
| | Aurora-coMpound 1 Preparation Products And Raw materials |
|